Titre
Pharmacodynamic and humoral effects of single intravenous doses of captopril in normal subjects.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Nussberger, J.
Auteure/Auteur
Waeber, G.
Auteure/Auteur
Bidiville, J.
Auteure/Auteur
Waeber, B.
Auteure/Auteur
Brunner, H.R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1064-1963
Statut éditorial
Publié
Date de publication
1987
Volume
9
Numéro
2-3
Première page
345
Dernière page/numéro d’article
9
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial - Publication Status: ppublish
Résumé
The blood pressure, heart rate and humoral responses to single intravenous doses of the angiotensin converting enzyme inhibitor captopril were evaluated in 5 volunteers on a free salt intake. Each subject was given at one-week intervals a 1, 5 and 25 mg intravenous dose of captopril as well as the vehicle of captopril. The study was conducted in a single-blind fashion and the order of treatment phases was randomized. Captopril was found to inhibit the renin-angiotensin system in a dose-dependent fashion. A fall in circulating angiotensin II was observed with doses of 1 and 5 mg. Plasma angiotensin II was not detectable 15 min after the 25 mg dose. Acute inhibition of angiotensin converting enzyme with intravenous captopril had no effect on blood pressure and heart rate.
PID Serval
serval:BIB_9C0E224154B1
PMID
Date de création
2008-01-25T13:10:07.071Z
Date de création dans IRIS
2025-05-21T03:49:55Z