Titre
Converging patterns of aging-associated brain volume loss and tissue microstructure differences.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Taubert, M.
Auteure/Auteur
Roggenhofer, E.
Auteure/Auteur
Melie-Garcia, L.
Auteure/Auteur
Muller, S.
Auteure/Auteur
Lehmann, N.
Auteure/Auteur
Preisig, M.
Auteure/Auteur
Vollenweider, P.
Auteure/Auteur
Marques-Vidal, P.
Auteure/Auteur
Lutti, A.
Auteure/Auteur
Kherif, F.
Auteure/Auteur
Draganski, B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1558-1497
Statut éditorial
Publié
Date de publication
2020-04
Volume
88
Première page
108
Dernière page/numéro d’article
118
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Given the worldwide increasing socioeconomic burden of aging-associated brain diseases, there is pressing need to gain in-depth knowledge about the neurobiology of brain anatomy changes across the life span. Advances in quantitative magnetic resonance imaging sensitive to brain's myelin, iron, and free water content allow for a detailed in vivo investigation of aging-related changes while reducing spurious morphometry differences. Main aim of our study is to link previous morphometry findings in aging to microstructural tissue properties in a large-scale cohort (n = 966, age range 46-86 y). Addressing previous controversies in the field, we present results obtained with different approaches to adjust local findings for global effects. Beyond the confirmation of age-related atrophy, myelin, and free water decreases, we report proportionally steeper volume, iron, and myelin decline in sensorimotor and subcortical areas paralleled by free water increase. We demonstrate aging-related white matter volume, myelin, and iron loss in frontostriatal projections. Our findings provide robust evidence for spatial overlap between volume and tissue property differences in aging that affect predominantly motor and executive networks.
PID Serval
serval:BIB_411C556B69C2
PMID
Date de création
2020-02-17T14:31:02.958Z
Date de création dans IRIS
2025-05-20T16:00:20Z