Titre

Structure and Plasticity of Indoleamine 2,3-Dioxygenase 1 (IDO1).

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Röhrig, U.F.
Auteure/Auteur
Michielin, O.
Auteure/Auteur
Zoete, V.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1520-4804
Statut éditorial
Publié
Date de publication
2021-12-23
Volume
64
Numéro
24
Première page
17690
Dernière page/numéro d’article
17705
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Since the discovery of the implication of indoleamine 2,3-dioxygenase 1 (IDO1) in tumoral immune resistance in 2003, the search for inhibitors has been intensely pursued both in academia and in pharmaceutical companies, supported by the publication of the first crystal structure of IDO1 in 2006. More recently, it has become clear that IDO1 is an important player in various biological pathways and diseases ranging from neurodegenerative diseases to infection and autoimmunity. Its inhibition may lead to clinical benefit in different therapeutic settings. At present, over 50 experimental structures of IDO1 in complex with different ligands are available in the Protein Data Bank. Our analysis of this wealth of structural data sheds new light on several open issues regarding IDO1's structure and function.
PID Serval
serval:BIB_27218E957A69
DOI
PMID
WOS
Permalien
Date de création
2021-12-20T11:41:06.740Z
Date de création dans IRIS
2025-05-20T16:52:07Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

acs.jmedchem.1c01665.pdf

Version du manuscrit

published

Licence

https://creativecommons.org/licenses/by-nc-nd/4.0

Taille

4.48 MB

Format

Adobe PDF

PID Serval

serval:BIB_27218E957A69.P001

URN

urn:nbn:ch:serval-BIB_27218E957A692

Somme de contrôle

(MD5):4997d9164cb92439b3344fd1738640d3