Titre
Angiogenesehemmung in der Neuroonkologie. Eine vielversprechende Therapiestrategie gegen maligne Gliome [Angiogenesis inhibition in neurooncology. A very promising therapy strategy for malignant glioma]
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Tabatabai, G.
Auteure/Auteur
Stupp, R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1433-0407[electronic], 0028-2804[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
81
Numéro
8
Première page
936
Dernière page/numéro d’article
939
Langue
allemand
Résumé
The application of angiogenesis inhibitors in neurooncology is increasing. Initially, these drugs seemed to be very promising because of the surprisingly high neuroradiological response rates that were observed in first clinical trials. Meanwhile, this enthusiasm is waning, as the high response rates did not translate into substantial improvements in progression-free and overall survival. Tumor progression during or after antiangiogenic therapy is often associated with rapid clinical neurological deterioration and sometimes even with diffuse infiltrative gliomatosis-like neuroradiological phenotypes. Thus, the characterization and understanding of escape mechanisms are needed. The identification of criteria for defining the personalized use of angiogenesis inhibitors remains a challenge.
PID Serval
serval:BIB_4A8756B86657
PMID
Date de création
2010-09-01T12:08:48.053Z
Date de création dans IRIS
2025-05-20T14:01:28Z