Titre
Prophylaktische zytolytische Behandlung nach Herztransplantation: ATG versus OKT3. [Preventive cytolytic treatment following heart transplantation: ATG versus OKT3]
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Helvetica Chirurgica Acta
Auteur(s)
Laske, A.
Auteure/Auteur
Leonardi, L.
Auteure/Auteur
Gallino, A.
Auteure/Auteur
Bauer, E.
Auteure/Auteur
Carrel, T.
Auteure/Auteur
Schonbeck, M.
Auteure/Auteur
von Segesser, L. K.
Auteure/Auteur
Turina, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0018-0181
Statut éditorial
Publié
Date de publication
1991-01
Volume
57
Numéro
4
Première page
611
Dernière page/numéro d’article
7
Notes
English Abstract
Journal Article --- Old month value: Jan
Journal Article --- Old month value: Jan
Résumé
The postoperative prophylactic cytolytic therapy with rabbit-ATG and OKT3 after heart transplantation are compared. The first 20 recipients were treated with ATG (5 days), the next 20 with OKT3 (14 days). The medium histological rejection grade (Texas classification) was significantly higher after 2 weeks in ATG group and after 4 weeks in OKT3 group. The linearised rejection rate was 7.1 (ATG) vs. 0.7 (OKT3) (p less than 0.005) at 2 weeks, resp. 3.6 vs. 8.6 (p less than 0.05) and 1.3 vs. 2.9 (p less than 0.005) at 4 weeks and 2 months. After 3 months there was no difference in histological rejection grade (3.6 +/- 1.5 vs. 3.3 +/- 1.7) and linearised rejection rate (2.4 vs. 2.6 per 100 days and patient) between the two groups. Severe rejections are more frequent after OKT3 (6 vs. 11) and probability of rejection free survival is higher after ATG (25% vs. 0%, resp. 21% vs. 0% after 2 resp. 3 months; p less than 0.05). In this study we find no short and medium term benefit of a rejection prophylaxis with OKT3 (14 days) compared with ATG (5 days). Acute allograft rejections in OKT3 group tend to be more severe with a higher mortality.
Sujets
PID Serval
serval:BIB_27C848CC8FDA
PMID
Date de création
2008-02-14T13:18:18.590Z
Date de création dans IRIS
2025-05-20T19:10:51Z