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  4. Preferential infection of immature dendritic cells and B cells by mouse mammary tumor virus.
 
  • Détails
Titre

Preferential infection of immature dendritic cells and B cells by mouse mammary tumor virus.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Journal of Immunology  
Auteur(s)
Vacheron, S.
Auteure/Auteur
Luther, S.A.
Auteure/Auteur
Acha-Orbea, H.
Auteure/Auteur
Liens vers les personnes
Acha-Orbea, Hans  
Luther, Sanjiv  
Liens vers les unités
DIB - Dpt. d'immunobiologie  
Ludwig Institute for Cancer Research  
ISSN
0022-1767[print], 0022-1767[linking]
Statut éditorial
Publié
Date de publication
2002
Volume
168
Numéro
7
Première page
3470
Dernière page/numéro d’article
3476
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Until now it was thought that the retrovirus mouse mammary tumor virus preferentially infects B cells, which thereafter proliferate and differentiate due to superantigen-mediated T cell help. We describe in this study that dendritic cells are infectable at levels comparable to B cells in the first days after virus injection. Moreover, IgM knockout mice have chronically deleted superantigen-reactive T cells after MMTV injection, indicating that superantigen presentation by dendritic cells is sufficient for T cell deletion. In both subsets initially only few cells were infected, but there was an exponential increase in numbers of infected B cells due to superantigen-mediated T cell help, explaining that at the peak of the response infection is almost exclusively found in B cells. The level of infection in vivo was below 1 in 1000 dendritic cells or B cells. Infection levels in freshly isolated dendritic cells from spleen, Langerhans cells from skin, or bone marrow-derived dendritic cells were compared in an in vitro infection assay. Immature dendritic cells such as Langerhans cells or bone marrow-derived dendritic cells were infected 10- to 30-fold more efficiently than mature splenic dendritic cells. Bone marrow-derived dendritic cells carrying an endogenous mouse mammary tumor virus superantigen were highly efficient at inducing a superantigen response in vivo. These results highlight the importance of professional APC and efficient T cell priming for the establishment of a persistent infection by mouse mammary tumor virus.
Sujets

Adoptive Transfer

Animals

Antigen Presentation/...

B-Lymphocyte Subsets/...

B-Lymphocyte Subsets/...

CD4-Positive T-Lympho...

CD4-Positive T-Lympho...

Cell Differentiation/...

Cell Differentiation/...

Cells, Cultured

Clonal Deletion/genet...

Dendritic Cells/immun...

Dendritic Cells/patho...

Interphase/immunology...

Lymph Nodes/immunolog...

Lymph Nodes/pathology...

Lymphopenia/genetics

Lymphopenia/immunolog...

Mammary Tumor Virus, ...

Mice

Mice, Inbred BALB C

Mice, Inbred DBA

Mice, Knockout

Retroviridae Infectio...

Superantigens/biosynt...

Superantigens/immunol...

Tumor Virus Infection...

PID Serval
serval:BIB_E08993B57D6F
PMID
11907107
WOS
000174566400047
Permalien
https://iris.unil.ch/handle/iris/232312
Date de création
2008-01-24T13:48:25.402Z
Date de création dans IRIS
2025-05-21T05:13:50Z
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