Titre
Ložisková amyloidóza v dutině nosní [Localized Amyloidosis Involving the Nasal Cavity]
Type
article
Institution
Externe
Périodique
Klinicka onkologie
Auteur(s)
Koukalová, R.
Auteure/Auteur
Szturz, Petr
Auteure/Auteur
Svobodová, I.
Auteure/Auteur
Stulík, J.
Auteure/Auteur
Řehák, Z.
Auteure/Auteur
Liens vers les personnes
ISSN
0862-495X
Statut éditorial
Publié
Date de publication
2016
Volume
29
Numéro
3
Première page
216
Dernière page/numéro d’article
219
Peer-reviewed
Oui
Langue
tchèque
Notes
Publication types: Case Reports ; English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Amyloidosis is a disease characterized by deposits of abnormal protein known as amyloid in various organs and tissues. It can be classified into systemic or localized forms, the latter of which is less frequent. Deposition of amyloidogenic monoclonal light chains leads to the most common type of this disease called light-chain (AL) amyloidosis. (18)F-FDG positron emission tomography/ computed tomography hybrid imaging (FDG-PET/ CT) demonstrates tracer uptake usually in all patients with localized amyloidosis as opposed to the systemic form.
Herein, we present a case of an otherwise healthy 56-year-old women diagnosed with a nasal polyp on the right side. The biopsy results were consistent with amyloidosis. FDG-PET/ CT imaging revealed a pathological, metabolically active lesion measuring 11 × 9 mm with a maximum standardized uptake value (SUV(max)) of 3.47. No other distant pathological changes were identified. After a radical resection, the patient has been regularly followed-up with clinical and imaging methods (MRI, FDG-PET/ CT), both of which repeatedly showed normal findings with disease-free survival of 27 months. Thus, FDG-PET/ CT imaging plays an important role not only for obtaining the right diagnosis but also in the follow-up of patients after surgical resection. In accordance with the literature, this case report confirms that FDG-PET/ CT imaging holds promise as an auxiliary method for distinguishing between localized and systemic forms of amyloidosis.
Herein, we present a case of an otherwise healthy 56-year-old women diagnosed with a nasal polyp on the right side. The biopsy results were consistent with amyloidosis. FDG-PET/ CT imaging revealed a pathological, metabolically active lesion measuring 11 × 9 mm with a maximum standardized uptake value (SUV(max)) of 3.47. No other distant pathological changes were identified. After a radical resection, the patient has been regularly followed-up with clinical and imaging methods (MRI, FDG-PET/ CT), both of which repeatedly showed normal findings with disease-free survival of 27 months. Thus, FDG-PET/ CT imaging plays an important role not only for obtaining the right diagnosis but also in the follow-up of patients after surgical resection. In accordance with the literature, this case report confirms that FDG-PET/ CT imaging holds promise as an auxiliary method for distinguishing between localized and systemic forms of amyloidosis.
PID Serval
serval:BIB_07246CCAC624
PMID
Open Access
Oui
Date de création
2025-01-06T18:17:43.401Z
Date de création dans IRIS
2025-05-20T13:40:04Z