Titre
Effet anti-inflammatoire du diclofenac sodium topique (Voltarène Ophta) après trabéculoplastie au laser argon (TLA): résultats préliminaires d'une étude prospective en double-insu [Anti-inflammatory effect of topical diclofenac sodium (Voltarène Ophta) after argon laser trabeculoplasty: preliminary results of a prospective double-blind method].
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Herbort, C.P.
Auteure/Auteur
Mermoud, A.
Auteure/Auteur
Schnyder, C.
Auteure/Auteur
Pittet, N.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0023-2165
Statut éditorial
Publié
Date de publication
1992-05
Volume
200
Numéro
5
Première page
358
Dernière page/numéro d’article
361
Langue
français
Notes
Publication types: Clinical Trial ; English Abstract ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Publication Status: ppublish
Résumé
Using the laser flare-cell meter (LFMC), we have previously determined the intensity and pattern of post-ALT ocular inflammation. Inflammation peak occurs 48 hours after ALT and clinically relevant inflammation is seen in 100% of pigmentary glaucomas (PIG), 75% of pseudoexfoliative glaucomas (PEXG) but only in 25% of primary open angle glaucomas (POAG). We also showed that topical diclofenac reduced inflammation in all 17 treated patients. Prostaglandins are thought to play a major role in ALT-inflammation and it is therefore logical to assume that NSAID are effective in that situation and will probably advantageously replace corticosteroids. In order to assess the anti-inflammatory effect of diclofenac drops (Voltaren Ophtha) we included a total of 37 PIG or PEXG (19 in the diclofenac and 18 in the placebo group) scheduled for ALT in prospective randomized placebo-controlled study. Visual acuity, tonometry, and LFCM flare measure were performed before, 3, 6 hours, 1, 2, 4, 7, 14 days after ALT. Topical diclofenac or placebo was given before and after ALT and then QID for a total of 4 days. Mean maximal flare increase was significantly less in the diclofenac group than in the placebo group (4.6 +/- 3.8 ph/msec v. 17.4 +/- 19 ph/msec; p less than 0.01). Flare increase compared to pre-ALT values was significant at 1 and 2 days after ALT in the placebo group only (p less than 0.02; p less than 0.05); no significant flare increase occurred in the diclofenac group.(ABSTRACT TRUNCATED AT 250 WORDS)
PID Serval
serval:BIB_80FABC44B7EC
PMID
Date de création
2008-01-28T11:49:31.911Z
Date de création dans IRIS
2025-05-20T21:59:08Z