Titre
Technology Insight: small, noncoding RNA molecules as tools to study and treat endocrine diseases
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Nature Clinical Practice. Endocrinology and Metabolism
Auteur(s)
Kolfschoten, I. G.
Auteure/Auteur
Regazzi, R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1745-8374
Statut éditorial
Publié
Date de publication
2007-12
Volume
3
Numéro
12
Première page
827
Dernière page/numéro d’article
34
Notes
Journal Article --- Old month value: Dec
Résumé
The capacity of tiny, noncoding RNA molecules (including small, interfering RNA molecules and micro-RNA molecules [miRNAs]) to control gene expression in a very specific and efficient manner has opened new avenues in biomedical research. RNA interference (RNAi) is now an important tool able to specifically inhibit the expression of almost any gene. The understanding of the molecular determinants of endocrine diseases has benefited a great deal from the new opportunities offered by the use of RNAi. Because RNAi is able to specifically inhibit the expression of particular genes it has great therapeutic potential, and the first clinical trials have already started. The delivery of RNAi in vivo, however, requires different methods to those used in vitro. RNAi uses several components of a cellular pathway devoted to the production of miRNAs, a class of naturally occurring small, noncoding RNA molecules that function as translational repressors. There is growing evidence that miRNAs play key regulatory roles in several cellular processes, such as proliferation, differentiation and apoptosis, and recent publications have demonstrated that alterations in miRNA function might be involved in endocrine diseases, including diabetes mellitus, and in endocrine cancer.
PID Serval
serval:BIB_EA8E375BAEE4
PMID
Date de création
2008-01-24T13:29:59.461Z
Date de création dans IRIS
2025-05-20T22:57:05Z