Titre
MICA gene triplet repeat polymorphism in patients with HLA-B27 positive and negative ankylosing spondylitis from Sardinia
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Ricci-Vitiani, L.
Auteure/Auteur
Vacca, A.
Auteure/Auteur
Potolicchio, I.
Auteure/Auteur
Scarpa, R.
Auteure/Auteur
Bitti, P.
Auteure/Auteur
Sebastiani, G.
Auteure/Auteur
Passiu, G.
Auteure/Auteur
Mathieu, A.
Auteure/Auteur
Sorrentino, R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0315-162X
Statut éditorial
Publié
Date de publication
2000-09
Volume
27
Numéro
9
Première page
2193
Dernière page/numéro d’article
7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
OBJECTIVE: We investigated the distribution of MICA triplet repeat polymorphism in a random population and in patients with seronegative spondyloarthritis from Sardinia compared to continental Italy. METHODS: We analyzed the distribution of MICA triplet repeat polymorphism in HLA-B*2709 [not associated with ankylosing spondylitis (AS)] and B*2705 (associated with AS) haplotypes, to verify whether the strong association of MICA-A4 with HLA-B27 reported in other populations is maintained in Sardinia, and compared the distribution of MICA-A alleles in HLA-B27 negative versus HLA-B27+ patients with AS. RESULTS: We found that the frequency of MICA-A4 triplet repeat allele in a random Sardinia population is higher (53.2%) than in other Caucasian populations (around 20%); this allele is strongly associated with both HLA-B*2709 and B*2705. No significant difference between HLA-B27+ patients with AS and healthy controls was found: the MICA-A4 allele was present in more than 90% of subjects. MICA-A4 was found in 16 out of 20 HLA-B27 negative Sardinian patients with AS, with a frequency (80%) more similar to that of the HLA-B27+ group of patients than that of controls. CONCLUSION: The high frequency of MICA-A4 allele in HLA-B27 negative patients with AS from Sardinia, suggests the presence within the HLA region of a susceptibility factor other and certainly weaker than B27. This factor is likely to be more easily found by analyzing genetically homogeneous populations like the Sardinian, characterized by a small number of very frequent haplotypes.
Sujets
PID Serval
serval:BIB_6323E09D4B19
PMID
Date de création
2008-01-25T14:16:07.941Z
Date de création dans IRIS
2025-05-20T21:48:15Z