Titre
Intrathymic pathogenesis of myasthenia gravis: transient expression of acetylcholine receptors on thymus-derived myogenic cells
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Wekerle, H.
Auteure/Auteur
Ketelsen, U. P.
Auteure/Auteur
Zurn, A. D.
Auteure/Auteur
Fulpius, B. W.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0014-2980
Statut éditorial
Publié
Date de publication
1978-08
Volume
8
Numéro
8
Première page
579
Dernière page/numéro d’article
82
Notes
Journal Article --- Old month value: Aug
Résumé
Differentiation of myogenic stem cells from undifferentiated thymic stem cells is thought to play a critical role in the pathogenesis of myasthenia gravis. The expression of membrane acetylcholine receptor (AChR) on the membranes of developing muscle clones in cultures of murine thymus reticulum was followed and found to be transient. AChR are first expressed shortly after fusion of myotubes. In subsequent stages of myogenic development, the density of homogenously distributed AChR is strongly increased, and, in addition, concentrated "hot spot" AChR areas appear. During further maturation, membrane AChR are lost. Highly mature myotubes (3 months in culture) lack substantial amounts of homogenous AChR, as well as hot spots.
Sujets
PID Serval
serval:BIB_077600E29479
PMID
Date de création
2008-01-28T07:44:10.322Z
Date de création dans IRIS
2025-05-20T14:40:20Z