Titre
The transcriptional factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis.
Type
article
Institution
Externe
Périodique
Auteur(s)
Hsu, T.
Auteure/Auteur
Bagni, C.
Auteure/Auteur
Sutherland, J.D.
Auteure/Auteur
Kafatos, F.C.
Auteure/Auteur
Liens vers les personnes
ISSN
0890-9369
Statut éditorial
Publié
Date de publication
1996-06-01
Volume
10
Numéro
11
Première page
1411
Dernière page/numéro d’article
1421
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
Establishment of dorsoventral polarity during Drosophila oogenesis requires localized intercellular communication between the follicular cells and the oocyte. This is initiated by the transmission of a "dorsal signal" from the oocyte to the anterior dorsal follicle cells by the EGF receptor (EGF-R) pathway and is followed by transmission of a second signal from the ventral follicle cells back to the embryo. We show that the zinc finger transcription factor CF2 participates in these processes. CF2 is suppressed by EGF-R signaling in the anterior dorsal follicle cells. Altered expression patterns of CF2 result in specific dorsoventral patterning defects in egg chambers and in embryos, as demonstrated phenotypically and with molecular markers. CF2 appears to act as a repressor of dorsal follicle cell fates and specifically as a repressor of the rhomboid gene transcription.
PID Serval
serval:BIB_0EDBF783168E
PMID
Date de création
2017-03-06T16:23:50.025Z
Date de création dans IRIS
2025-05-20T20:06:27Z