Titre
Plasticity in the barrel cortex of the adult mouse: effects of chronic stimulation upon deoxyglucose uptake in the behaving animal
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Welker, E.
Auteure/Auteur
Rao, S. B.
Auteure/Auteur
Dorfl, J.
Auteure/Auteur
Melzer, P.
Auteure/Auteur
van der Loos, H.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0270-6474
Statut éditorial
Publié
Date de publication
1992-01
Volume
12
Numéro
1
Première page
153
Dernière page/numéro d’article
70
Notes
Journal Article --- Old month value: Jan
Résumé
We investigated experience-dependent regulation of neuronal activity in the whisker-to-barrel pathway of the adult mouse using the autoradiographic deoxyglucose (DG) method. Animals were placed in the Lausanne whisker stimulator, and three of their whisker follicles were passively stimulated for a period of 1, 2, or 4 d. After this period, mice received a dose of DG and were placed in a cage containing a pile of wooden sticks. Mice that underwent the same procedure except the passive stimulation served as controls. Patterns of stimulus-dependent DG uptake were studied in the somatosensory cortex and in the trigeminal sensory brainstem complex. DG uptake in the barrels corresponding to the passively stimulated whiskers was lower than in controls. This decrease was present throughout the radial extent of a barrel column and was observed in all passively stimulated animals. Quantitative analysis confirmed these observations and, furthermore, showed a statistically significant decrease in DG uptake in barrels neighboring the passively stimulated ones. In half of the animals, the brainstem nuclei showed a decreased DG uptake in the representation of the passively stimulated whiskers, whereas in the other animals the pattern of DG uptake was as in controls. We propose that the signs of cortical plasticity are due to a mechanism that operates in layer IV and functions as a gate for peripheral sensory activity to enter cortical circuitry.
Sujets
PID Serval
serval:BIB_7D859245EF74
PMID
Date de création
2008-01-24T13:40:42.629Z
Date de création dans IRIS
2025-05-20T23:03:53Z
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Nom
153.full.pdf
Version du manuscrit
published
Taille
7.03 MB
Format
Adobe PDF
PID Serval
serval:BIB_7D859245EF74.P001
URN
urn:nbn:ch:serval-BIB_7D859245EF748
Somme de contrôle
(MD5):be0619877a6c058a018b21ea3f659135