Titre
Rotavirus specific plasma secretory immunoglobulin in children with acute gastroenteritis and children vaccinated with an attenuated human rotavirus vaccine.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Herrera, D.
Auteure/Auteur
Vásquez, C.
Auteure/Auteur
Corthésy, B.
Auteure/Auteur
Franco, M.A.
Auteure/Auteur
Angel, J.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2164-554X
Statut éditorial
Publié
Date de publication
2013
Volume
9
Numéro
11
Première page
2409
Dernière page/numéro d’article
2417
Langue
anglais
Résumé
Rotavirus (RV)-specific secretory immunoglobulin (RV-SIg) has been previously detected in serum of naturally RV infected children and shown to reflect the intestinal Ig immune response. Total plasma SIgA and plasma RV-SIg were evaluated by ELISA in children with gastroenteritis due or not due to RV infection and in 50 children vaccinated with the attenuated RIX4414 human RV vaccine and 62 placebo recipients. RV-SIg was only detected in children with evidence of previous RV infection or with acute RV gastroenteritis. Vaccinees had higher RV-SIg titers than placebo recipients and RV-SIg titers increased after the second vaccine dose. RV-SIg measured after the second dose correlated with protection when vaccinees and placebo recipients were analyzed jointly. RV-SIg may serve as a valuable correlate of protection for RV vaccines.
PID Serval
serval:BIB_5D04A24689CF
PMID
Date de création
2014-03-07T17:00:21.683Z
Date de création dans IRIS
2025-05-20T17:05:25Z