Titre
Effectiveness of a Standardized and Specific Follow-Up in Memory Centers in Patients with Alzheimer's Disease.
Type
article
Institution
Externe
Périodique
Auteur(s)
Rouch, L.
Auteure/Auteur
Cestac, P.
Auteure/Auteur
Cool, C.
Auteure/Auteur
Helmer, C.
Auteure/Auteur
Dartigues, J.F.
Auteure/Auteur
Berr, C.
Auteure/Auteur
Rouaud, O.
Auteure/Auteur
Vellas, B.
Auteure/Auteur
Andrieu, S.
Auteure/Auteur
Groupes de travail
REAL-FR Study Group and the 3C Study Group
Liens vers les personnes
ISSN
1875-5828
Statut éditorial
Publié
Date de publication
2017
Volume
14
Numéro
3
Première page
255
Dernière page/numéro d’article
267
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
To compare the 4-year survival, institutionalization, cognitive and functional decline of Alzheimer's patients with specific follow-up in memory centers versus usual care.
Four year longitudinal follow-up.
The French Network of memory centers in Alzheimer's disease (REAL-FR study) and The French population-based study (3C study).
728 patients aged ≥ 65, living at home, meeting criteria for probable Alzheimer's disease and having Mini Mental State Examination (MMSE) scores between 10 and 26 at baseline were included.
Cox proportional hazards models were performed to test the effectiveness of a specific follow-up in memory centers (REAL-FR study) versus usual care (3C study) on the 4-year survival and institutionalization. Linear mixed models were used to assess cognitive and functional decline in both groups.
After adjustment for confounding factors, the 4-year survival did not differ significantly between patients followed-up in memory centers and those who had recourse to usual care (usual care: Hazard Ratio adjusted (HRa) = 0.87, 95% confidence interval (CI) 0.53-1.43, p=0.59). Patients with a specific follow-up in memory centers had a higher risk of being institutionalized (usual care: HRa = 0.24, 95% CI 0.12-0.48, p<0.001). They also exhibited a significant greater cognitive and functional decline over time.
Our findings failed to demonstrate any potential benefits of a specific follow-up in memory centers on clinically meaningful outcomes in the natural history of Alzheimer's disease. Recourse to care in memory centers may have been the consequence of a faster dementia progression and a greater burden of Alzheimer's disease, all leading to detrimental consequences on various prognostic outcomes.
Four year longitudinal follow-up.
The French Network of memory centers in Alzheimer's disease (REAL-FR study) and The French population-based study (3C study).
728 patients aged ≥ 65, living at home, meeting criteria for probable Alzheimer's disease and having Mini Mental State Examination (MMSE) scores between 10 and 26 at baseline were included.
Cox proportional hazards models were performed to test the effectiveness of a specific follow-up in memory centers (REAL-FR study) versus usual care (3C study) on the 4-year survival and institutionalization. Linear mixed models were used to assess cognitive and functional decline in both groups.
After adjustment for confounding factors, the 4-year survival did not differ significantly between patients followed-up in memory centers and those who had recourse to usual care (usual care: Hazard Ratio adjusted (HRa) = 0.87, 95% confidence interval (CI) 0.53-1.43, p=0.59). Patients with a specific follow-up in memory centers had a higher risk of being institutionalized (usual care: HRa = 0.24, 95% CI 0.12-0.48, p<0.001). They also exhibited a significant greater cognitive and functional decline over time.
Our findings failed to demonstrate any potential benefits of a specific follow-up in memory centers on clinically meaningful outcomes in the natural history of Alzheimer's disease. Recourse to care in memory centers may have been the consequence of a faster dementia progression and a greater burden of Alzheimer's disease, all leading to detrimental consequences on various prognostic outcomes.
Sujets
PID Serval
serval:BIB_000B01039AB3
PMID
Date de création
2024-08-23T10:31:55.032Z
Date de création dans IRIS
2025-05-20T19:02:37Z