Titre
Pancreatic beta-cell mass in European subjects with type 2 diabetes.
Type
article
Institution
Externe
Auteur(s)
Rahier, J.
Auteure/Auteur
Guiot, Y.
Auteure/Auteur
Goebbels, R.M.
Auteure/Auteur
Sempoux, C.
Auteure/Auteur
Henquin, J.C.
Auteure/Auteur
Liens vers les personnes
ISSN
1463-1326
Statut éditorial
Publié
Date de publication
2008
Volume
10
Numéro
Suppl 4
Première page
32
Dernière page/numéro d’article
42
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Decreases in both beta-cell function and number can contribute to insulin deficiency in type 2 diabetes. Here, we quantified the beta-cell mass in pancreas obtained at autopsy of 57 type 2 diabetic (T2D) and 52 non-diabetic subjects of European origin. Sections from the body and tail were immunostained for insulin. The beta-cell mass was calculated from the volume density of beta-cells (measured by point-counting methods) and the weight of the pancreas. The pancreatic insulin concentration was measured in some of the subjects. beta-cell mass increased only slightly with body mass index (BMI). After matching for BMI, the beta-cell mass was 41% (BMI < 25) and 38% (BMI 26-40) lower in T2D compared with non-diabetic subjects, and neither gender nor type of treatment influenced these differences. beta-cell mass did not correlate with age at diagnosis but decreased with duration of clinical diabetes (24 and 54% lower than controls in subjects with <5 and >15 years of overt diabetes respectively). Pancreatic insulin concentration was 30% lower in patients. In conclusion, the average beta-cell mass is about 39% lower in T2D subjects compared with matched controls. Its decrease with duration of the disease could be a consequence of diabetes that, with further impairment of insulin secretion, contributes to the progressive deterioration of glucose homeostasis. We do not believe that the small difference in beta-cell mass observed within 5 years of onset could cause diabetes in the absence of beta-cell dysfunction.
PID Serval
serval:BIB_B150046B7E0C
PMID
Date de création
2015-01-19T10:26:00.710Z
Date de création dans IRIS
2025-05-21T02:16:58Z