Titre
Functional neurogenesis in the adult hippocampus.
Type
article
Institution
Externe
Périodique
Auteur(s)
van Praag, H.
Auteure/Auteur
Schinder, A.F.
Auteure/Auteur
Christie, B.R.
Auteure/Auteur
Toni, N.
Auteure/Auteur
Palmer, T.D.
Auteure/Auteur
Gage, F.H.
Auteure/Auteur
Liens vers les personnes
ISSN
0028-0836
Statut éditorial
Publié
Date de publication
2002
Volume
415
Numéro
6875
Première page
1030
Dernière page/numéro d’article
1034
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Résumé
There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We report that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells. Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain.
PID Serval
serval:BIB_E11A0AAED00D
PMID
Date de création
2010-01-22T06:56:28.792Z
Date de création dans IRIS
2025-05-21T05:10:11Z