Titre
Autoregulation of glucose production in health and disease
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Tappy, L.
Auteure/Auteur
Chiolero, R.
Auteure/Auteur
Berger, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1363-1950
Statut éditorial
Publié
Date de publication
1999-03
Volume
2
Numéro
2
Première page
161
Dernière page/numéro d’article
4
Notes
Journal Article
Review --- Old month value: Mar
Review --- Old month value: Mar
Résumé
Plasma glucose concentration is a major regulator of glucose production in experimental animals and in humans. Hyperglycemia inhibits and hypoglycemia stimulates glucose production through mechanisms which are, in part, independent of changes in glucoregulatory hormones. Glucose production does not change when gluconeogenesis is acutely inhibited or stimulated. These observations indicate an autoregulatory process by which hepatic glucose production is altered as a direct consequence of changes in glycemia. Data obtained in patients with glucokinase gene mutations indicate that glucokinase may play a role in this regulatory process. Hyperglycemia in type 2 diabetic patients and in critically ill patients may result from a blunted effect of hyperglycemia on glucose production.
Sujets
PID Serval
serval:BIB_205B0BE753EB
PMID
Date de création
2008-01-24T12:36:24.389Z
Date de création dans IRIS
2025-05-20T19:13:40Z