Titre
Programmed cell death: NINJ1 and mechanisms of plasma membrane rupture.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Trends in biochemical sciences
Auteur(s)
Ramos, S.
Auteure/Auteur
Hartenian, E.
Auteure/Auteur
Broz, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0968-0004
Statut éditorial
Publié
Date de publication
2024-08
Volume
49
Numéro
8
Première page
717
Dernière page/numéro d’article
728
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Lytic cell death culminates in cell swelling and plasma membrane rupture (PMR). The cellular contents released, including proteins, metabolites, and nucleic acids, can act as danger signals and induce inflammation. During regulated cell death (RCD), lysis is actively initiated and can be preceded by an initial loss of membrane integrity caused by pore-forming proteins, allowing small molecules and cytokines to exit the cell. A recent seminal discovery showed that ninjurin1 (NINJ1) is the common executioner of PMR downstream of RCD, resulting in the release of large proinflammatory molecules and representing a novel target of cell death-associated lysis. We summarize recent developments in understanding membrane integrity and rupture of the plasma membrane with a focus on NINJ1.
PID Serval
serval:BIB_B7387FE546AF
PMID
Date de création
2024-06-28T10:27:37.262Z
Date de création dans IRIS
2025-05-20T21:46:47Z