Titre
Sex steroid regulation of the hypothalamo-pituitary-adrenal axis activity in middle-aged mice during endotoxic shock
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Suescun, M.
Auteure/Auteur
Chisari, A. N.
Auteure/Auteur
Carino, M.
Auteure/Auteur
Hadid, R.
Auteure/Auteur
Gaillard, R. C.
Auteure/Auteur
Spinedi, E.
Auteure/Auteur
Liens vers les personnes
rgaillar
Liens vers les unités
ISSN
1021-7401
Statut éditorial
Publié
Date de publication
1994-10
Volume
1
Numéro
5
Première page
315
Dernière page/numéro d’article
20
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep-Oct
Research Support, Non-U.S. Gov't --- Old month value: Sep-Oct
Résumé
Many studies have documented the presence of a sexually dimorphic response of neuroendocrine functions in response to immune signals. The aims of the present study were to evaluate the hypothalamopituitary-adrenal (HPA) axis response to inflammatory stress stimulus in 15-month-old mice, and to determine whether such a response depends on circulating sex steroids. Our results indicate that in the 15-month-old mice: (1) there is a sexual dimorphism in the HPA axis activity in basal condition and after endotoxin treatment with generally higher levels of several parameters of this axis in female than in male mice, (2) gonadectomy alone, followed by sex steroid therapy, modulates HPA axis function in both basal and stress conditions, and (3) whereas estradiol plays a stimulatory role on adrenal function, testosterone inhibits adrenal glucocorticoid production. This study further suggests a clear sexual dimorphism in middle-aged mice injected with endotoxin. These results may be relevant for the treatment of sepsis in aged patients.
Sujets
PID Serval
serval:BIB_F134AFBC9B18
PMID
Date de création
2008-02-15T15:58:19.467Z
Date de création dans IRIS
2025-05-21T05:29:48Z