Titre
Retrograde neurotrophin-mediated control of neurone survival in the developing central nervous system.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Primi, M.P.
Auteure/Auteur
Clarke, P.G.H.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0959-4965[print], 0959-4965[linking]
Statut éditorial
Publié
Date de publication
1996
Volume
7
Numéro
2
Première page
473
Dernière page/numéro d’article
476
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jan 31
Résumé
Neuronal death in vertebrate development is widely believed to be regulated by retrograde survival signals from the axonal target territory, and these signals are assumed to be initiated by the binding of trophic molecules to the axon terminal. However, direct evidence for the retrograde transmission of such survival signals along developing axons is only available in the peripheral nervous system. We show here in a central projection, the isthmo-optic projection of chick embryos, that a neurotrophin, brain-derived neurotrophic factor, can indeed initiate retrograde survival signals from the target territory. A related molecule, neurotrophin-3, is ineffective.
Sujets
PID Serval
serval:BIB_A4B487A41844
PMID
Date de création
2008-01-20T16:49:16.550Z
Date de création dans IRIS
2025-05-21T00:39:48Z