Titre

Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Minocha, S.
Auteure/Auteur
Valloton, D.
Auteure/Auteur
Ypsilanti, A.R.
Auteure/Auteur
Fiumelli, H.
Auteure/Auteur
Allen, E.A.
Auteure/Auteur
Yanagawa, Y.
Auteure/Auteur
Marin, O.
Auteure/Auteur
Chédotal, A.
Auteure/Auteur
Hornung, J.P.
Auteure/Auteur
Lebrand, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2041-1723
Statut éditorial
Publié
Date de publication
2015
Volume
6
Première page
6887
Peer-reviewed
Oui
Langue
anglais
Résumé
Guidepost cells present at and surrounding the midline provide guidance cues that orient the growing axons through commissures. Here we show that the transcription factor Nkx2.1 known to control the specification of GABAergic interneurons also regulates the differentiation of astroglia and polydendrocytes within the mouse anterior commissure (AC). Nkx2.1-positive glia were found to originate from three germinal regions of the ventral telencephalon. Nkx2.1-derived glia were observed in and around the AC region by E14.5. Thereafter, a selective cell ablation strategy showed a synergistic role of Nkx2.1-derived cells, both GABAergic interneurons and astroglia, towards the proper formation of the AC. Finally, our results reveal that the Nkx2.1-regulated cells mediate AC axon guidance through the expression of the repellent cue, Slit2. These results bring forth interesting insights about the spatial and temporal origin of midline telencephalic glia, and highlight the importance of neurons and astroglia towards the formation of midline commissures.
PID Serval
serval:BIB_12B7E201A8FA
DOI
PMID
WOS
Permalien
Open Access
Oui
Date de création
2015-06-10T05:41:32.600Z
Date de création dans IRIS
2025-05-20T14:20:55Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

BIB_12B7E201A8FA.P001.pdf

Version du manuscrit

published

Licence

https://creativecommons.org/licenses/by/4.0

Taille

6.48 MB

Format

Adobe PDF

PID Serval

serval:BIB_12B7E201A8FA.P001

URN

urn:nbn:ch:serval-BIB_12B7E201A8FA7

Somme de contrôle

(MD5):51f8e988ab3a23f05fad209a703353cd