Titre
TLR2 modulates inflammation in zymosan-induced arthritis in mice
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Frasnelli, M. E.
Auteure/Auteur
Tarussio, D.
Auteure/Auteur
Chobaz-Peclat, V.
Auteure/Auteur
Busso, N.
Auteure/Auteur
So, A.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1478-6362
Statut éditorial
Publié
Date de publication
2005
Volume
7
Numéro
2
Première page
R370
Dernière page/numéro d’article
9
Notes
Journal Article
Résumé
The interplay between the innate and acquired immune systems in chronic inflammation is not well documented. We have investigated the mechanisms of inflammation in murine zymosan-induced arthritis (ZIA) in the light of recent data on the roles of Toll-like receptor 2 (TLR2) and Dectin-1 in the activation of monocyte/macrophages by zymosan. The severity of inflammation, joint histology, lymphocyte proliferation and antibody production in response to zymosan were analyzed in mice deficient in TLR2 and complement C3, and the effects of Dectin-1 inhibition by laminarin were studied. In comparison with wild-type animals, TLR2-deficient mice showed a significant decrease in the early (day 1) and late phases (day 24) of joint inflammation. C3-deficient mice showed no differences in technetium uptake or histological scoring. TLR2-deficient mice also showed a significant decrease in lymph node cell proliferation in response to zymosan and a lower IgG antibody response to zymosan at day 25 in comparison with wild-type controls, indicating that TLR2 signalling has a role in the development of acquired immune responses to zymosan. Although laminarin, a soluble beta-glucan, was able to significantly inhibit zymosan uptake by macrophages in vitro, it had no effect on ZIA in vivo. These results show that ZIA is more prolonged than was originally described and involves both the innate and acquired immune pathways. C3 does not seem to have a major role in this model of joint inflammation.
Sujets
PID Serval
serval:BIB_553119B57151
PMID
Open Access
Oui
Date de création
2008-01-25T07:38:41.778Z
Date de création dans IRIS
2025-05-20T15:32:29Z
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Nom
BIB_553119B57151.P001.pdf
Version du manuscrit
preprint
Taille
589.72 KB
Format
Adobe PDF
PID Serval
serval:BIB_553119B57151.P001
URN
urn:nbn:ch:serval-BIB_553119B571511
Somme de contrôle
(MD5):36142aac6007f447ec1da9a3dc11090b