Titre
Tolerance and reactivity of NK cells: two sides of the same coin?
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Held, W.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0014-2980
Statut éditorial
Publié
Date de publication
2008
Volume
38
Numéro
11
Première page
2930
Dernière page/numéro d’article
2933
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
NK cells can kill transformed, infected and stressed cells while most normal cells are spared. NK cells are activated by various endogenous self-ligands, some of which are actually expressed by normal cells. Thus, NK cells are inherently self-reactive and consequently, potentially auto-aggressive. How these cells are prevented from attacking normal cells while ensuring reactivity to diseased cells is a major unresolved question for NK-cell biologists.
PID Serval
serval:BIB_7F187459146D
PMID
Open Access
Oui
Date de création
2009-10-12T13:46:59.790Z
Date de création dans IRIS
2025-05-21T02:06:42Z