Titre
Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus.
Type
article
Institution
Externe
Périodique
PLoS biology
Auteur(s)
Jessberger, S.
Auteure/Auteur
Aigner, S.
Auteure/Auteur
Clemenson, G.D.
Auteure/Auteur
Toni, N.
Auteure/Auteur
Lie, D.C.
Auteure/Auteur
Karalay, O.
Auteure/Auteur
Overall, R.
Auteure/Auteur
Kempermann, G.
Auteure/Auteur
Gage, F.H.
Auteure/Auteur
Liens vers les personnes
ISSN
1545-7885[electronic]
Statut éditorial
Publié
Date de publication
2008
Volume
6
Numéro
11
Première page
e272
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Newborn granule cells become functionally integrated into the synaptic circuitry of the adult dentate gyrus after a morphological and electrophysiological maturation process. The molecular mechanisms by which immature neurons and the neurites extending from them find their appropriate position and target area remain largely unknown. Here we show that single-cell-specific knockdown of cyclin-dependent kinase 5 (cdk5) activity in newborn cells using a retrovirus-based strategy leads to aberrant growth of dendritic processes, which is associated with an altered migration pattern of newborn cells. Even though spine formation and maturation are reduced in cdk5-deficient cells, aberrant dendrites form ectopic synapses onto hilar neurons. These observations identify cdk5 to be critically involved in the maturation and dendrite extension of newborn neurons in the course of adult neurogenesis. The data presented here also suggest a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation.
Sujets
PID Serval
serval:BIB_98F5BE651602
PMID
Open Access
Oui
Date de création
2010-01-22T06:43:12.664Z
Date de création dans IRIS
2025-05-20T21:40:21Z