Titre
Platelet and Neutrophil Counts as Predictive Markers of Neoadjuvant Therapy Efficacy in Rectal Cancer.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Policicchio, A.
Auteure/Auteur
Mercier, J.
Auteure/Auteur
Digklia, A.
Auteure/Auteur
Voutsadakis, I.A.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1941-6636
Statut éditorial
Publié
Date de publication
2019-12
Volume
50
Numéro
4
Première page
894
Dernière page/numéro d’article
900
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
To investigate pretreatment platelet and neutrophil counts as well as a combined platelet-neutrophil (PN) index for prognostic information in patients with rectal adenocarcinoma that received neoadjuvant treatment.
Charts from 164 patients with localized rectal adenocarcinoma were retrospectively reviewed, and 112 patients with complete data were included in the study. Patients were stratified in groups according to their neutrophil counts, platelet counts, and a combined platelet/neutrophil (PN) index. Baseline parameters of the groups were compared using the x <sup>2</sup> test. Pathologic responses on the surgical specimen of patients with lower platelet counts (≤ 350 × 10 <sup>9</sup> /L), lower neutrophil counts (≤ 7.5 × 10 <sup>9</sup> /L), and a lower PN index were compared with those of patients with higher platelet counts (> 350 × 10 <sup>9</sup> /L), higher neutrophil counts (> 7.5 × 10 <sup>9</sup> /L), and a higher PN index using the x <sup>2</sup> test. Kaplan-Meier curves of overall and progression free survival were constructed and compared with the log-rank test.
A total of 33 (29.5%) patients belonged to the high-PN index group, and 79 (70.9%) patients belonged to the low-PN index group. A significant difference was present between the two groups with regard to pathologic response. Patients with both high platelet and high neutrophil counts were less likely to have a complete pathologic response than those in the low-PN index group (P = 0.039). Additionally, tumor location and tumor stage were significantly associated with complete pathologic response to neoadjuvant treatment. Patients with a complete response were more likely to present with a low tumor (≤ 5 cm from the anal verge). Likewise, patients diagnosed with stage II disease were more likely to experience complete response than those diagnosed with stage III (x <sup>2</sup> test P = 0.016). There was no significant difference in overall and progression free survival between the two platelet groups (log-rank P = 0.73 and 0.40, respectively) and the two PN index groups (log-rank P = 0.92 and 0.43, respectively).
In this retrospective analysis, the combination of higher platelet and neutrophil counts at the time of diagnosis had predictive value with respect to complete pathologic response to neoadjuvant treatment in locally advanced rectal cancer.
Charts from 164 patients with localized rectal adenocarcinoma were retrospectively reviewed, and 112 patients with complete data were included in the study. Patients were stratified in groups according to their neutrophil counts, platelet counts, and a combined platelet/neutrophil (PN) index. Baseline parameters of the groups were compared using the x <sup>2</sup> test. Pathologic responses on the surgical specimen of patients with lower platelet counts (≤ 350 × 10 <sup>9</sup> /L), lower neutrophil counts (≤ 7.5 × 10 <sup>9</sup> /L), and a lower PN index were compared with those of patients with higher platelet counts (> 350 × 10 <sup>9</sup> /L), higher neutrophil counts (> 7.5 × 10 <sup>9</sup> /L), and a higher PN index using the x <sup>2</sup> test. Kaplan-Meier curves of overall and progression free survival were constructed and compared with the log-rank test.
A total of 33 (29.5%) patients belonged to the high-PN index group, and 79 (70.9%) patients belonged to the low-PN index group. A significant difference was present between the two groups with regard to pathologic response. Patients with both high platelet and high neutrophil counts were less likely to have a complete pathologic response than those in the low-PN index group (P = 0.039). Additionally, tumor location and tumor stage were significantly associated with complete pathologic response to neoadjuvant treatment. Patients with a complete response were more likely to present with a low tumor (≤ 5 cm from the anal verge). Likewise, patients diagnosed with stage II disease were more likely to experience complete response than those diagnosed with stage III (x <sup>2</sup> test P = 0.016). There was no significant difference in overall and progression free survival between the two platelet groups (log-rank P = 0.73 and 0.40, respectively) and the two PN index groups (log-rank P = 0.92 and 0.43, respectively).
In this retrospective analysis, the combination of higher platelet and neutrophil counts at the time of diagnosis had predictive value with respect to complete pathologic response to neoadjuvant treatment in locally advanced rectal cancer.
Sujets
PID Serval
serval:BIB_9FB09F99885C
PMID
Date de création
2018-11-05T08:01:24.026Z
Date de création dans IRIS
2025-05-21T03:52:52Z