Titre
Substrate metabolism, nutrient balance and obesity development in children and adolescents: a target for intervention?
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Sun, M.
Auteure/Auteur
Schutz, Y.
Auteure/Auteur
Maffeis, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1467-7881
Statut éditorial
Publié
Date de publication
2004-11
Volume
5
Numéro
4
Première page
183
Dernière page/numéro d’article
188
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Obesity results from the organism's inability to maintain energy balance over a long term. Childhood obesity and its related factors and pathological consequences tend to persist into adulthood. A cluster of factors, including high energy density in the diet (high fat intake), low energy expenditure, and disturbed substrate oxidation, favour the increase in fat mass. Oxidation of three major macronutrients and their roles in the regulation of energy balance, particularly in children and adolescents, are discussed. Total glucose oxidation is not different between obese and lean children; exogenous glucose utilization is higher whereas endogenous glucose utilization is lower in obese compared with lean children. Carbohydrate composition of the diet determines carbohydrate oxidation regardless of fat content of the diet. Both exogenous and endogenous fat oxidation are higher in obese than in lean subjects. The influence of high fat intake on accumulation of fat mass is operative rather over a long term. Several future directions are addressed, such that a combination of increased physical activity and modification in diet composition, in terms of energy density and glycemic index, is recommended for children and adolescents.
Sujets
PID Serval
serval:BIB_5591FE752F8F
PMID
Date de création
2008-01-21T12:09:35.989Z
Date de création dans IRIS
2025-05-20T19:23:43Z