Titre
Fate of potentially self-reactive T cells in neonatal mice: analysis of V beta 6+ T cells in Mlsa mice
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Thymus
Auteur(s)
Schneider, R.
Auteure/Auteur
Lees, R.
Auteure/Auteur
Pedrazzini, T.
Auteure/Auteur
Odermatt, B.
Auteure/Auteur
Speiser, D. E.
Auteure/Auteur
Zinkernagel, R. M.
Auteure/Auteur
Hengartner, H.
Auteure/Auteur
MacDonald, H. R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0165-6090
Statut éditorial
Publié
Date de publication
1989
Volume
13
Numéro
1-2
Première page
35
Dernière page/numéro d’article
43
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Résumé
FACS analysis of either CD4 or CD8 depleted thymocytes revealed, that in adult Mlsa mice among CD4+ or CD8+ subpopulation of mature T cells V beta 6+ cells were absent. In contrast neonatal Mlsa mice had CD4+ V beta 6+ cells that rapidly decreased after day 4. On thymus cryosections of neonatal DBA/2 (Mlsa) mice V beta 6+ cells were found both in the cortex and the medulla of the thymus, in addition V beta 6+ cells were also detected in lymph nodes. After day 7-8 V beta 6+ cells disappeared from the medulla and the periphery. In the adult thymus only dull staining V beta 6+ cells were present in the cortex. Comparison of the fluorescence intensities of V beta 6 staining thymocytes from neonatally with Mlsa spleen cells tolerized mice with that of untreated BALB/c controls showed a significant decrease in T cell receptor density. Neonatal V beta 6+ T cells could be shown to be autoreactive against Mlsa, this reactivity declined at about the same time when the stimulatory capacity of Mlsa was established and could be first shown on day 4.
Sujets
PID Serval
serval:BIB_FC645CE7A5AF
PMID
Date de création
2008-01-28T10:32:54.997Z
Date de création dans IRIS
2025-05-21T05:59:23Z