Titre
Characterizing the relationship between BOLD contrast and regional cerebral blood flow measurements by varying the stimulus presentation rate.
Type
article
Institution
Externe
Périodique
Auteur(s)
Rees, G.
Auteure/Auteur
Howseman, A.
Auteure/Auteur
Josephs, O.
Auteure/Auteur
Frith, C.D.
Auteure/Auteur
Friston, K.J.
Auteure/Auteur
Frackowiak, R.S.
Auteure/Auteur
Turner, R.
Auteure/Auteur
Liens vers les personnes
ISSN
1053-8119
Statut éditorial
Publié
Date de publication
1997
Volume
6
Numéro
4
Première page
270
Dernière page/numéro d’article
278
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
This paper investigates the relationship between the blood oxygenation level dependent (BOLD) contrast effect and regional cerebral blood flow using the techniques of functional MRI (fMRI) and positron emission tomography (PET). A passive listening paradigm with parametric variation in word presentation rate was used to investigate the rate dependency of both BOLD contrast fMRI and H215O PET in primary auditory cortex. We attempted to equate the stimulus presentation acoustic environments by using prerecorded echoplanar imaging sounds during the PET paradigm. We show that there is a linear relationship between word presentation rate and cerebral blood flow in primary auditory cortex, whereas the relationship between BOLD contrast and stimulus presentation rate is highly nonlinear, showing a saturable effect. Two possible explanations for our results are discussed: a nonlinearity in the relationship between BOLD contrast and deoxyhemoglobin concentration or a nonlinear rate dependency of the physiological mechanisms causing changes in deoxyhemoglobin concentration.
PID Serval
serval:BIB_FCDAFC131712
PMID
Date de création
2011-09-16T15:34:03.777Z
Date de création dans IRIS
2025-05-21T05:31:38Z