Titre
Metabolic and respiratory effects of infused sodium acetate in healthy human subjects.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Burnier, P.
Auteure/Auteur
Tappy, L.
Auteure/Auteur
Jéquier, E.
Auteure/Auteur
Schneeberger, D.
Auteure/Auteur
Chioléro, R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0363-6119
Statut éditorial
Publié
Date de publication
1992
Volume
263
Numéro
6 Pt 2
Première page
R1271
Dernière page/numéro d’article
R1276
Langue
anglais
Résumé
The metabolic and respiratory effects of intravenous 0.5 M sodium acetate (at a rate of 2.5 mmol/min during 120 min) were studied in nine normal human subjects. O2 consumption (VO2) and CO2 production (VCO2) were measured continuously by open-circuit indirect calorimetry. VO2 increased from 251 +/- 9 to 281 +/- 9 ml/min (P < 0.001), energy expenditure increased from 4.95 +/- 0.17 kJ/min baseline to 5.58 +/- 0.16 kJ/min (P < 0.001), and VCO2 decreased nonsignificantly (211 +/- 7 ml/min vs. 202 +/- 7 ml/min, NS). The extrapulmonary CO2 loss (i.e., bicarbonate generation and excretion) was estimated at 48 +/- 5 ml/min. This observation is consistent with 1 mol of bicarbonate generated from 1 mol of acetate metabolized. Alveolar ventilation decreased from 3.5 +/- 0.2 l/min basal to 3.1 +/- 0.2 l/min (P < 0.001). The minute ventilation (VE) to VO2 ratio decreased from 22.9 +/- 1.3 to 17.6 +/- 0.9 l/l (P < 0.005), arterial PO2 decreased from 93.2 +/- 1.9 to 78.7 +/- 1.6 mmHg (P < 0.0001), arterial PCO2 increased from 39.2 +/- 0.7 to 42.1 +/- 1.1 mmHg (P < 0.0001), pH from 7.40 +/- 0.005 to 7.50 +/- 0.007 (P < 0.005), and arterial bicarbonate concentration from 24.2 +/- 0.7 to 32.9 +/- 1.1 (P < 0.0001). These observations indicate that sodium acetate infusion results in substantial extrapulmonary CO2 loss, which leads to a relative decrease of total and alveolar ventilation.
PID Serval
serval:BIB_03E8C62FB99F
PMID
Date de création
2008-01-24T12:36:07.001Z
Date de création dans IRIS
2025-05-20T18:00:14Z