Titre
Automated detection of local normalization areas for ictal-interictal subtraction brain SPECT
Type
article
Institution
Externe
Périodique
Auteur(s)
Boussion, N.
Auteure/Auteur
Houzard, C.
Auteure/Auteur
Ostrowsky, K.
Auteure/Auteur
Ryvlin, P.
Auteure/Auteur
Mauguiere, F.
Auteure/Auteur
Cinotti, L.
Auteure/Auteur
Liens vers les personnes
ISSN
0161-5505
Statut éditorial
Publié
Date de publication
2002-11
Volume
43
Numéro
11
Première page
1419
Dernière page/numéro d’article
25
Langue
anglais
Notes
Boussion, Nicolas
Houzard, Claire
Ostrowsky, Karine
Ryvlin, Philippe
Mauguiere, Francois
Cinotti, Luc
eng
J Nucl Med. 2002 Nov;43(11):1419-25.
Houzard, Claire
Ostrowsky, Karine
Ryvlin, Philippe
Mauguiere, Francois
Cinotti, Luc
eng
J Nucl Med. 2002 Nov;43(11):1419-25.
Résumé
UNLABELLED: Whole-brain activity is often chosen to quantitatively normalize peri-ictal and interictal SPECT scans before their subtraction. This use is not justified, because significant and extended modification of the cerebral blood flow can occur during a seizure. We validated and compared 2 automatic methods able to determine the optimal reference region, using simulation and clinical data. METHODS: In the first method, the selected reference region is the intersection of peri-ictal-interictal areas with no significantly different z values. The other method relies on a 3-dimensional iterative voxel aggregation. The increase of the selected volume is stopped by using 2 different variance tests (Levene and SE). These algorithms were tested on 39 epileptic patients and were validated using 1 interictal and 10 peri-ictal scans simulated from the mean image of 22 healthy subjects. RESULTS: In the patient studies, the mean relative activity of the selected regions, compared with whole-brain activity (classic normalization), was 122.6%. Their average relative size (compared with the size of the whole brain) was 33.2% for the z map method, 22.8% for the SE test, and 11.8% for the Levene test. After application of our automatic processes, subtraction of the simulated images revealed a recovery of abnormal regions up to 45% larger than the region obtained with classic normalization. CONCLUSION: These results illustrate the role of normalization on the subtracted peri-ictal and interictal images. Our methods are automatic and objective and give good results on various simulated images. The z map construction is worth considering because it is simple, selects large parts of the brain, and requires little computation time.
PID Serval
serval:BIB_89476FEFE573
PMID
Date de création
2018-11-29T11:36:44.224Z
Date de création dans IRIS
2025-05-21T03:41:42Z