Titre
Association of grip strength with cardiovascular risk markers.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Gubelmann, C.
Auteure/Auteur
Vollenweider, P.
Auteure/Auteur
Marques-Vidal, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2047-4881
Statut éditorial
Publié
Date de publication
2017-03
Volume
24
Numéro
5
Première page
514
Dernière page/numéro d’article
521
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Background Mechanisms underlying the association between grip strength and cardiovascular mortality are poorly understood. We aimed to assess the association of grip strength with a panel of cardiovascular risk markers. Design The study was based on a cross-sectional analysis of 3468 adults aged 50-75 years (1891 women) from a population-based sample in Lausanne, Switzerland. Methods Grip strength was measured using a hydraulic hand dynamometer. Cardiovascular risk markers included anthropometry, blood pressure, lipids, glucose, adiposity, inflammatory and other metabolic markers. Results In both genders, grip strength was negatively associated with fat mass (Pearson correlation coefficient: women: -0.170, men: -0.198), systolic blood pressure (women: -0.096, men: -0.074), fasting glucose (women: -0.048, men: -0.071), log-transformed leptin (women: -0.074, men: -0.065), log-transformed high-sensitivity C-reactive protein (women: -0.101, men: -0.079) and log-transformed homocysteine (women: -0.109, men: -0.060). In men, grip strength was also positively associated with diastolic blood pressure (0.068), total (0.106) and low density lipoprotein-cholesterol (0.082), and negatively associated with interleukin-6 (-0.071); in women, grip strength was negatively associated with triglycerides (-0.064) and uric acid (-0.059). After multivariate adjustment, grip strength was negatively associated with waist circumference (change per 5 kg increase in grip strength: -0.82 cm in women and -0.77 cm in men), fat mass (-0.56% in women; -0.27% in men) and high-sensitivity C-reactive protein (-6.8% in women; -3.2% in men) in both genders, and with body mass index (0.22 kg/m javax.xml.bind.JAXBElement@165be361 ) and leptin (-2.7%) in men. Conclusion Grip strength shows only moderate associations with cardiovascular risk markers. The effect of muscle strength as measured by grip strength on cardiovascular disease does not seem to be mediated by cardiovascular risk markers.
Sujets
PID Serval
serval:BIB_F0E51BCD521B
PMID
Open Access
Oui
Date de création
2016-11-28T12:15:08.355Z
Date de création dans IRIS
2025-05-21T05:14:25Z
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Nom
5_27885059_Postprint.pdf
Version du manuscrit
postprint
Taille
616.98 KB
Format
Adobe PDF
PID Serval
serval:BIB_F0E51BCD521B.P001
URN
urn:nbn:ch:serval-BIB_F0E51BCD521B5
Somme de contrôle
(MD5):3f82962af1945a8ed02d7d0717ff9ec0