Golgi-Resident Gαo Promotes Protrusive Membrane Dynamics.

Katanaev, V.L.

doi:10.1016/j.cell.2017.07.015

Titre

Golgi-Resident Gαo Promotes Protrusive Membrane Dynamics.

Type

article

Institution

UNIL/CHUV/Unisanté + institutions partenaires

Périodique

Cell

Auteur(s)

Solis, G.P.

Auteure/Auteur

Bilousov, O.

Auteure/Auteur

Koval, A.

Auteure/Auteur

Lüchtenborg, A.M.

Auteure/Auteur

Lin, C.

Auteure/Auteur

Katanaev, V.L.

Auteure/Auteur

Liens vers les personnes

Katanaev, Vladimir

Koval, Alexey

Bilousov, Oleksii

Solis Padilla, Gonzalo

Liens vers les unités

DPT- Dpt pharmacologie et de toxicologie

Dép. des Sciences Biomédicales

Groupe Katanaev

ISSN

1097-4172

Statut éditorial

Publié

Date de publication

2017-08-24

Volume

170

Numéro

5

Première page

939

Dernière page/numéro d’article

955.e24

Peer-reviewed

Oui

Langue

anglais

Notes

Publication types: Journal Article
Publication Status: ppublish

Résumé

To form protrusions like neurites, cells must coordinate their induction and growth. The first requires cytoskeletal rearrangements at the plasma membrane (PM), the second requires directed material delivery from cell's insides. We find that the Gαo-subunit of heterotrimeric G proteins localizes dually to PM and Golgi across phyla and cell types. The PM pool of Gαo induces, and the Golgi pool feeds, the growing protrusions by stimulated trafficking. Golgi-residing KDELR binds and activates monomeric Gαo, atypically for G protein-coupled receptors that normally act on heterotrimeric G proteins. Through multidimensional screenings identifying > 250 Gαo interactors, we pinpoint several basic cellular activities, including vesicular trafficking, as being regulated by Gαo. We further find small Golgi-residing GTPases Rab1 and Rab3 as direct effectors of Gαo. This KDELR → Gαo → Rab1/3 signaling axis is conserved from insects to mammals and controls material delivery from Golgi to PM in various cells and tissues.

PID Serval

serval:BIB_794947CE9347

DOI

10.1016/j.cell.2017.07.015

PMID

28803726

WOS

000408372400013

Permalien

https://iris.unil.ch/handle/iris/201318

Date de création

2017-09-25T06:29:04.412Z

Date de création dans IRIS

2025-05-21T02:42:16Z

Fichier(s)

Nom

28803726_AuthorManuscript.pdf

Version du manuscrit

postprint

Taille

4.26 MB

Format

Adobe PDF

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URN

urn:nbn:ch:serval-BIB_794947CE93476

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Format

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Taille

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Format

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