Titre
Dual energy computed tomography cannot effectively differentiate between calcium pyrophosphate and basic calcium phosphate diseases in the clinical setting.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Jarraya, M.
Auteure/Auteur
Bitoun, O.
Auteure/Auteur
Wu, D.
Auteure/Auteur
Balza, R.
Auteure/Auteur
Guermazi, A.
Auteure/Auteur
Collins, J.
Auteure/Auteur
Gupta, R.
Auteure/Auteur
Nielsen, G.P.
Auteure/Auteur
Guermazi, E.
Auteure/Auteur
Simeone, F.J.
Auteure/Auteur
Omoumi, P.
Auteure/Auteur
Melnic, C.M.
Auteure/Auteur
Yee, S.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2665-9131
Statut éditorial
Publié
Date de publication
2024-03
Volume
6
Numéro
1
Première page
100436
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Recent reports suggested that dual-energy CT (DECT) may help discriminate between different types of calcium phosphate crystals in vivo, which would have important implications for the characterization of crystal deposition occurring in osteoarthritis.
Our aim was to test the hypothesis that DECT can effectively differentiate basic calcium phosphate (BCP) from calcium pyrophosphate (CPP) deposition diseases.
Discarded tissue after total knee replacement specimens in a 71 year-old patient with knee osteoarthritis and chondrocalcinosis was scanned using DECT at standard clinical parameters. Specimens were then examined on light microscopy which revealed CPP deposition in 4 specimens (medial femoral condyle, lateral tibial plateau and both menisci) without BCP deposition. Regions of interest were placed on post-processed CT images using Rho/Z maps (Syngo.via, Siemens Healthineers, VB10B) in different areas of CPP deposition, trabecular bone BCP (T-BCP) and subchondral bone plate BCP (C-BCP).
Dual Energy Index (DEI) of CPP was 0.12 (SD = 0.02) for reader 1 and 0.09 (SD = 0.03) for reader 2, The effective atomic number (Z <sub>eff</sub> ) of CPP was 10.83 (SD = 0.44) for reader 1 and 10.11 (SD = 0.66) for reader 2. Nearly all DECT parameters of CPP were higher than those of T-BCP, lower than those of C-BCP, and largely overlapping with Aggregate-BCP (aggregate of T-BCP and C-BCP).
Differentiation of different types of calcium crystals using DECT is not feasible in a clinical setting.
Our aim was to test the hypothesis that DECT can effectively differentiate basic calcium phosphate (BCP) from calcium pyrophosphate (CPP) deposition diseases.
Discarded tissue after total knee replacement specimens in a 71 year-old patient with knee osteoarthritis and chondrocalcinosis was scanned using DECT at standard clinical parameters. Specimens were then examined on light microscopy which revealed CPP deposition in 4 specimens (medial femoral condyle, lateral tibial plateau and both menisci) without BCP deposition. Regions of interest were placed on post-processed CT images using Rho/Z maps (Syngo.via, Siemens Healthineers, VB10B) in different areas of CPP deposition, trabecular bone BCP (T-BCP) and subchondral bone plate BCP (C-BCP).
Dual Energy Index (DEI) of CPP was 0.12 (SD = 0.02) for reader 1 and 0.09 (SD = 0.03) for reader 2, The effective atomic number (Z <sub>eff</sub> ) of CPP was 10.83 (SD = 0.44) for reader 1 and 10.11 (SD = 0.66) for reader 2. Nearly all DECT parameters of CPP were higher than those of T-BCP, lower than those of C-BCP, and largely overlapping with Aggregate-BCP (aggregate of T-BCP and C-BCP).
Differentiation of different types of calcium crystals using DECT is not feasible in a clinical setting.
PID Serval
serval:BIB_4FA4FE5A2AF9
PMID
Open Access
Oui
Date de création
2024-02-26T12:29:58.816Z
Date de création dans IRIS
2025-05-20T14:58:26Z
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Nom
38384979_BIB_4FA4FE5A2AF9.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
971.61 KB
Format
Adobe PDF
PID Serval
serval:BIB_4FA4FE5A2AF9.P001
URN
urn:nbn:ch:serval-BIB_4FA4FE5A2AF96
Somme de contrôle
(MD5):31598d1baf4666634955472b7fb4ede8