Titre
Metabolic predictors of obesity. Contribution of resting energy expenditure, thermic effect of food, and fuel utilization to four-year weight gain of post-obese and never-obese women.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Weinsier, R.L.
Auteure/Auteur
Nelson, K.M.
Auteure/Auteur
Hensrud, D.D.
Auteure/Auteur
Darnell, B.E.
Auteure/Auteur
Hunter, G.R.
Auteure/Auteur
Schutz, Y.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0021-9738
Statut éditorial
Publié
Date de publication
1995-03
Volume
95
Numéro
3
Première page
980
Dernière page/numéro d’article
985
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
This prospective study was designed to identify abnormalities of energy expenditure and fuel utilization which distinguish post-obese women from never-obese controls. 24 moderately obese, postmenopausal, nondiabetic women with a familial predisposition to obesity underwent assessments of body composition, fasting and postprandial energy expenditure, and fuel utilization in the obese state and after weight loss (mean 12.9 kg) to a post-obese, normal-weight state. The post-obese women were compared with 24 never-obese women of comparable age and body composition. Four years later, without intervention, body weight was reassessed in both groups. Results indicated that all parameters measured in the post-obese women were similar to the never-obese controls: mean resting energy expenditure, thermic effect of food, and fasting and postprandial substrate oxidation and insulin-glucose patterns. Four years later, post-obese women regained a mean of 10.9 kg while control subjects remained lean (mean gain 1.7 kg) (P < 0.001 between groups). Neither energy expenditure nor fuel oxidation correlated with 4-yr weight changes, whereas self-reported physical inactivity was associated with greater weight regain. The data suggest that weight gain in obesity-prone women may be due to maladaptive responses to the environment, such as physical inactivity or excess energy intake, rather than to reduced energy requirements.
PID Serval
serval:BIB_C3FD30F2F43C
PMID
Date de création
2008-01-21T12:08:18.696Z
Date de création dans IRIS
2025-05-21T02:24:07Z