Titre
MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Fanger, G. R.
Auteure/Auteur
Gerwins, P.
Auteure/Auteur
Widmann, C.
Auteure/Auteur
Jarpe, M. B.
Auteure/Auteur
Johnson, G. L.
Auteure/Auteur
Liens vers les personnes
ISSN
0959-437X
Statut éditorial
Publié
Date de publication
1997-02
Volume
7
Numéro
1
Première page
67
Dernière page/numéro d’article
74
Notes
Journal Article
Review --- Old month value: Feb
Review --- Old month value: Feb
Résumé
Regulation of the mitogen-activated protein kinase (MAPK) family members - which include the extracellular response kinases (ERKs), p38/HOG1, and the c-Jun amino-terminal kinases (JNKs) - plays a central role in mediating the effects of diverse stimuli encompassing cytokines, hormones, growth factors and stresses such as osmotic imbalance, heat shock, inhibition of protein synthesis and irradiation. A rapidly increasing number of kinases that activate the JNK pathways has been described recently, including the MAPK/ERK kinase kinases, p21-activated kinases, germinal center kinase, mixed lineage kinases, tumor progression locus 2, and TGF-beta-activated kinase. Thus, regulation of the JNK pathway provides an interesting example of how many different stimuli can converge into regulating pathways critical for the determination of cell fate.
Sujets
PID Serval
serval:BIB_AF20524811C4
PMID
Date de création
2008-01-24T13:43:29.910Z
Date de création dans IRIS
2025-05-20T21:16:52Z