Titre
Combined positron emission tomography and magnetic resonance imaging for the planning of stereotactic brain biopsies in children: experience in 9 cases.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Pirotte, B.
Auteure/Auteur
Goldman, S.
Auteure/Auteur
Salzberg, S.
Auteure/Auteur
Wikler, D.
Auteure/Auteur
David, P.
Auteure/Auteur
Vandesteene, A.
Auteure/Auteur
Van Bogaert, P.
Auteure/Auteur
Salmon, I.
Auteure/Auteur
Brotchi, J.
Auteure/Auteur
Levivier, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1016-2291
Statut éditorial
Publié
Date de publication
2003
Volume
38
Numéro
3
Première page
146
Dernière page/numéro d’article
155
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Because brain tumors can be histologically heterogeneous, stereotactic brain biopsies (SBB) may lead to inaccurate diagnosis or grading. Positron emission tomography (PET) has been used in pediatric neuro-oncology to help in the understanding and management of brain neoplasms. We combined PET and magnetic resonance (MR) imaging in the planning of SBB in 9 children (5 males and 4 females, aged 2-14 years) with infiltrative, ill-defined brain lesions. Tracers used for PET were (18)F-2-fluoro-2-deoxy-D-glucose in 4 cases, (11)C-methionine in 2 cases and both tracers in 3 cases. Biopsy targets were selected in hypermetabolic areas. PET-guided SBB provided accurate histological diagnosis in all patients and allowed a reduction of the number of trajectories in lesions located in functional areas. It also helped in better understanding and management of complex cases. This preliminary series suggests that combining PET and MR imaging in the planning of SBB in children (1) improves the diagnostic yield of SBB in infiltrative, ill-defined brain lesions, (2) makes it possible to reduce the sampling in high-risk/functional areas and (3) improves the quality of therapeutic management of pediatric brain tumors.
Sujets
PID Serval
serval:BIB_D25C4A90A15B
PMID
Date de création
2008-01-20T16:35:28.044Z
Date de création dans IRIS
2025-05-20T21:50:36Z