Titre
Concussion burden and later-life cardiovascular risk factors in former professional American-style football players.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Tan, C.O.
Auteure/Auteur
Grashow, R.
Auteure/Auteur
Thorpe, R.
Auteure/Auteur
Miller, K.K.
Auteure/Auteur
Nathan, D.M.
Auteure/Auteur
Izzy, S.
Auteure/Auteur
Radmanesh, F.
Auteure/Auteur
Kim, J.H.
Auteure/Auteur
Weisskopf, M.G.
Auteure/Auteur
Taylor, H.A.
Auteure/Auteur
Zafonte, R.D.
Auteure/Auteur
Baggish, A.L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2328-9503
Statut éditorial
Publié
Date de publication
2024-06
Volume
11
Numéro
6
Première page
1604
Dernière page/numéro d’article
1614
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Mid-life cardiovascular risk factors are associated with later cognitive decline. Whether repetitive head injury among professional athletes impacts cardiovascular risk is unknown. We investigated associations between concussion burden and postcareer hypertension, high cholesterol, and diabetes among former professional American-style football (ASF) players.
In a cross-sectional study of 4080 professional ASF players conducted between January 2015 and March 2022, we used an mulitsymptom concussion symptom score (CSS) and the number of loss-of-consciousness (LOC) episodes as a single severe symptom to quantify football-related concussion exposure. Primary outcomes were hypertension, dyslipidemia, and diabetes, defined by current or recommended prescription medication use.
The prevalence of hypertension, high cholesterol, and diabetes among former players (52 ± 14 years of age) was 37%, 34%, and 9%. Concussion burden was significantly associated with hypertension (lowest vs. highest CSS quartile, odds ratio (OR) = 1.99; 95%CI: 1.33-2.98; p < 0.01) and high cholesterol (lowest vs. moderate CSS, OR = 1.46, 95%CI, 1.11-1.91; p < 0.01), but not diabetes. In fully adjusted models, the prevalence of multiple CVD was associated with CSS. These results were driven by younger former players (≤ 40 year of age) in which the odds of hypertension were over three times higher in those in the highest CSS quartile (OR = 3.29, 95%CI: 1.39-7.61; p = 0.01). Results were similar for LOC analyses.
Prior concussion burden is associated with postcareer atherogenic cardiovascular risk profiles among former professional American football players.
In a cross-sectional study of 4080 professional ASF players conducted between January 2015 and March 2022, we used an mulitsymptom concussion symptom score (CSS) and the number of loss-of-consciousness (LOC) episodes as a single severe symptom to quantify football-related concussion exposure. Primary outcomes were hypertension, dyslipidemia, and diabetes, defined by current or recommended prescription medication use.
The prevalence of hypertension, high cholesterol, and diabetes among former players (52 ± 14 years of age) was 37%, 34%, and 9%. Concussion burden was significantly associated with hypertension (lowest vs. highest CSS quartile, odds ratio (OR) = 1.99; 95%CI: 1.33-2.98; p < 0.01) and high cholesterol (lowest vs. moderate CSS, OR = 1.46, 95%CI, 1.11-1.91; p < 0.01), but not diabetes. In fully adjusted models, the prevalence of multiple CVD was associated with CSS. These results were driven by younger former players (≤ 40 year of age) in which the odds of hypertension were over three times higher in those in the highest CSS quartile (OR = 3.29, 95%CI: 1.39-7.61; p = 0.01). Results were similar for LOC analyses.
Prior concussion burden is associated with postcareer atherogenic cardiovascular risk profiles among former professional American football players.
PID Serval
serval:BIB_9C0B95B78348
PMID
Open Access
Oui
Date de création
2024-06-14T08:11:03.745Z
Date de création dans IRIS
2025-05-20T23:38:21Z
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Nom
38808967.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
850.38 KB
Format
Adobe PDF
PID Serval
serval:BIB_9C0B95B78348.P001
URN
urn:nbn:ch:serval-BIB_9C0B95B783489
Somme de contrôle
(MD5):e72008f36cb9242e413c60f93d1f109e