Titre
Left atrial adaptation in ischemic heart disease: insights from a cardiovascular magnetic resonance study.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Pavon, A.G.
Auteure/Auteur
Masci, P.G.
Auteure/Auteur
Pucci, L.
Auteure/Auteur
Landi, A.
Auteure/Auteur
Bermano, A.
Auteure/Auteur
Vaxman, A.
Auteure/Auteur
Gotsman, C.
Auteure/Auteur
Rutz, T.
Auteure/Auteur
Monney, P.
Auteure/Auteur
Godihno, R.
Auteure/Auteur
Saraiva Rodrigues, D.
Auteure/Auteur
Muller, O.
Auteure/Auteur
Valgimigli, M.
Auteure/Auteur
Schwitter, J.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1875-8312
Statut éditorial
Publié
Date de publication
2022-02-17
Volume
38
Première page
1533–1543
Peer-reviewed
Oui
Langue
anglais
Résumé
Left atrium (LA) plays a key role in the overall cardiac performance. However, it remains unclear how LA adapts, in terms of function and volumes, to left ventricular dysfunction in the acute and post-acute phases of myocardial infarction. LA volumes and function were evaluated in patients in the acute phase of ST-segment elevation myocardial infarction (acute-STEMI group) and in the post-acute phase after STEMI (post-acute STEMI group). Ten age and sex-matched healthy controls served as control group. In all subjects LA was assessed by a compressed-sensing cine pulse sequence and by a 3D non-model-based reconstruction. LV infarct size and microvascular obstruction were determined on late-gadolinium-enhancement data and LV myocardial oedema and myocardial haemorrhage were measured on T <sub>2</sub> -mapping data. Indexed LA maximum and minimum volumes did not differ between the acute (n = 50) and post-acute (n = 47) STEMI groups. LA active emptying fraction (LA <sub>AEF</sub> ) was higher in the acute-STEMI as compared with the post-acute STEMI groups (0.63 ± 0.23 vs 0.37 ± 0.24, p < 0.0001). Conversely, LA passive emptying fraction (LA <sub>PEF</sub> ) was lower in the acute-STEMI compared with post-acute-STEMI (0.34 ± 0.15 vs 0.65 ± 0.15, p < 0.0001) patients. In the acute-STEMI group, LA <sub>AEF</sub> was positively and LA <sub>PEF</sub> negatively correlated with LV myocardial tissue damage (r = 0.523 p = 0.0001; r = - 0.451 p = 0.0013). Negative and positive correlations were also found between LA <sub>AEF</sub> and LA <sub>PEF</sub> and time after STEMI (r = - 0.559 p = 0.0013 and r = 0.589 p = 0.0006, respectively). LA increases its active contractile function in the acute phase of STEMI to support LV filling. The extent (but not the type) of LV damage determines LA adaptions which normalizes over time.
PID Serval
serval:BIB_B8793EB2AF0A
PMID
Date de création
2022-03-01T10:42:43.014Z
Date de création dans IRIS
2025-05-20T21:16:37Z