Titre
Actin-related proteins in the nucleus: life beyond chromatin remodelers.
Type
article
Institution
Externe
Périodique
Auteur(s)
Dion, V.
Auteure/Auteur
Shimada, K.
Auteure/Auteur
Gasser, S.M.
Auteure/Auteur
Liens vers les personnes
ISSN
1879-0410
Statut éditorial
Publié
Date de publication
2010
Volume
22
Numéro
3
Première page
383
Dernière page/numéro d’article
391
Langue
anglais
Résumé
Since their discovery in the mid-1990s, nuclear actin-related proteins (ARPs) have gained attention for their roles as structural components of ATP-dependent chromatin-remodeling complexes. These remodelers can move nucleosomes along the DNA, evict them from chromatin, and exchange histone variants to alter chromatin states locally. Chromatin-remodeling facilitates DNA-templated processes such as transcription regulation, DNA replication, and repair. Consistent with a role for ARPs in shaping chromatin structure, recent genetic studies show that they affect developmental and cell-type specific transcriptional programming. Here, we focus on recent results that suggest a specific contribution of ARPs to long-range interactions in the nucleus, and review evidence indicating that some ARPs may act independently of chromatin-remodeling machines.
PID Serval
serval:BIB_5B619E590F9A
PMID
Date de création
2014-02-12T15:16:18.816Z
Date de création dans IRIS
2025-05-20T18:54:41Z