Titre
High-density lipoprotein, beta cells, and diabetes .
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
von Eckardstein, A.
Auteure/Auteur
Widmann, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1755-3245
Statut éditorial
Publié
Date de publication
2014
Volume
103
Numéro
3
Première page
384
Dernière page/numéro d’article
394
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
High-density lipoproteins (HDLs) exert a series of potentially beneficial effects on many cell types including anti-atherogenic actions on the endothelium and macrophage foam cells. HDLs may also exert anti-diabetogenic functions on the beta cells of the endocrine pancreas, notably by potently inhibiting stress-induced cell death and enhancing glucose-stimulated insulin secretion. HDLs have also been found to stimulate insulin-dependent and insulin-independent glucose uptake into skeletal muscle, adipose tissue, and liver. These experimental findings and the inverse association of HDL-cholesterol levels with the risk of diabetes development have generated the notion that appropriate HDL levels and functionality must be maintained in humans to diminish the risks of developing diabetes. In this article, we review our knowledge on the beneficial effects of HDLs in pancreatic beta cells and how these effects are mediated. We discuss the capacity of HDLs to modulate endoplasmic reticulum stress and how this affects beta-cell survival. We also point out the gaps in our understanding on the signalling properties of HDLs in beta cells. Hopefully, this review will foster the interest of scientists in working on beta cells and diabetes to better define the cellular pathways activated by HDLs in beta cells. Such knowledge will be of importance to design therapeutic tools to preserve the proper functioning of the insulin-secreting cells in our body.
PID Serval
serval:BIB_D1343223C2F1
PMID
Open Access
Oui
Date de création
2014-11-06T18:17:55.127Z
Date de création dans IRIS
2025-05-20T23:20:50Z
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Nom
5_24903496_Postprint.pdf
Version du manuscrit
postprint
Taille
718.27 KB
Format
Adobe PDF
PID Serval
serval:BIB_D1343223C2F1.P001
URN
urn:nbn:ch:serval-BIB_D1343223C2F10
Somme de contrôle
(MD5):965c35fccdb6297eb0911d01918e0b1e