Titre
Protein kinase C activity and subcellular distribution in rat brain following repeated electroconvulsive seizures
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Vernet, O.
Auteure/Auteur
Rostworowski, K.
Auteure/Auteur
Sherwin, A. L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0014-4886
Statut éditorial
Publié
Date de publication
1992-02
Volume
115
Numéro
2
Première page
297
Dernière page/numéro d’article
301
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
Protein kinase C (PKC) activity was measured in samples of neocortex, cerebellum, and hippocampus from adult rats receiving a series of 10 electroconvulsive seizures (ECS). Rats were sacrificed immediately and at various intervals from 15 min to 24 h after the last seizure. From 77 to 84% of total PKC activity was found in the cytosol versus the membrane fraction. PKC activity in cerebellum was significantly higher than in neocortex (15%, P less than 0.05). Repeated ECS treatment did not affect total PKC activity nor its distribution between membrane and cytosolic fractions when compared with sham ECS controls. This finding is in keeping with reports that adrenergic-stimulated phosphoinositol turnover is not altered 24 h following repeated ECS.
Sujets
PID Serval
serval:BIB_286592C5544E
PMID
Date de création
2008-01-25T12:13:17.160Z
Date de création dans IRIS
2025-05-20T19:11:30Z