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  4. Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease.
 
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Titre

Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease.

Type
article
Institution
Externe
Périodique
Alimentary Pharmacology and Therapeutics  
Auteur(s)
Lang, B.M.
Auteure/Auteur
Biedermann, L.
Auteure/Auteur
van Haaften, W.T.
Auteure/Auteur
de Vallière, C.
Auteure/Auteur
Schuurmans, M.
Auteure/Auteur
Begré, S.
Auteure/Auteur
Zeitz, J.
Auteure/Auteur
Scharl, M.
Auteure/Auteur
Turina, M.
Auteure/Auteur
Greuter, T.
Auteure/Auteur
Schreiner, P.
Auteure/Auteur
Heinrich, H.
Auteure/Auteur
Kuntzen, T.
Auteure/Auteur
Vavricka, S.R.
Auteure/Auteur
Rogler, G.
Auteure/Auteur
Beerenwinkel, N.
Auteure/Auteur
Misselwitz, B.
Auteure/Auteur
Contributrices/contributeurs
Anderegg, C.
Bauerfeind, P.
Beglinger, C.
Begré, S.
Bengoa, J.M.
Biedermann, L.
Bigler, B.
Binek, J.
Blattmann, M.
Boehm, S.
Borovicka, J.
Braegger, C.P.
Brunner, N.
Bühr, P.
Burnand, B.
Burri, E.
Buyse, S.
Cremer, M.
Criblez, D.H.
de Saussure, P.
Degen, L.
Delarive, J.
Doerig, C.
Dora, B.
Dorta, G.
Egger, M.
Ehmann, T.
El-Wafa, A.
Engelmann, M.
Ezri, A.
Felley, C.
Fliegner, M.
Fournier, N.
Fraga, M.
Frei, P.
Frei, R.
Fried, M.
Froehlich, F.
Funk, C.
Furlano, R.I.
Gallot-Lavallée, S.
Geyer, M.
Girardin, M.
Golay, D.
Grandinetti, T.
Gysi, B.
Haack, H.
Haarer, J.
Helbling, B.
Hengstler, P.
Herzog, D.
Hess, C.
Heyland, K.
Hinterleitner, T.
Hiroz, P.
Hirschi, C.
Hruz, P.
Iwata, R.
Jost, R.
Juillerat, P.
Kessler Brondolo, V.
Knellwolf, C.
Knoblauch, C.
Köhler, H.
Koller, R.
Krieger-Grübel, C.
Kullak-Ublick, G.
Künzler, P.
Landolt, M.
Lange, R.
Lehmann, F.S.
Macpherson, A.
Maerten, P.
Maillard, M.H.
Manser, C.
Manz, M.
Marbet, U.
Marx, G.
Matter, C.
McLin, V.
Meier, R.
Mendanova, M.
Meyenberger, C.
Michetti, P.
Misselwitz, B.
Moradpour, D.
Morell, B.
Mosler, P.
Mottet, C.
Müller, C.
Müller, P.
Müllhaupt, B.
Münger-Beyeler, C.
Musso, L.
Nagy, A.
Neagu, M.
Nichita, C.
Niess, J.
Noël, N.
Nydegger, A.
Obialo, N.
Oneta, C.
Oropesa, C.
Peter, U.
Peternac, D.
Petit, L.M.
Piccoli-Gfeller, F.
Pilz, J.B.
Pittet, V.
Raschle, N.
Rentsch, R.
Restellini, S.
Richterich, J.P.
Rihs, S.
Ritz, M.A.
Roduit, J.
Rogler, D.
Rogler, G.
Rossel, J.B.
Sagmeister, M.
Saner, G.
Sauter, B.
Sawatzki, M.
Schäppi, M.
Scharl, M.
Schelling, M.
Schibli, S.
Schlauri, H.
Uebelhart, S.S.
Schnegg, J.F.
Schoepfer, A.
Seibold, F.
Seirafi, M.
Semadeni, G.M.
Semela, D.
Senning, A.
Sidler, M.
Sokollik, C.
Spalinger, J.
Spangenberger, H.
Stadler, P.
Steuerwald, M.
Straumann, A.
Straumann-Funk, B.
Sulz, M.
Thorens, J.
Tiedemann, S.
Tutuian, R.
Vavricka, S.
Viani, F.
Vögtlin, J.
Von Känel, R.
Vonlaufen, A.
Vouillamoz, D.
Vulliamy, R.
Wermuth, J.
Werner, H.
Wiesel, P.
Wiest, R.
Wylie, T.
Zeitz, J.
Zimmermann, D.
Groupes de travail
Swiss IBD Cohort Study Group
Liens vers les personnes
Nydegger, Andreas  
Fraga Christinet, Montserrat  
Scharl, Majda  
ISSN
1365-2036
Statut éditorial
Publié
Date de publication
2018-01
Volume
47
Numéro
1
Première page
55
Dernière page/numéro d’article
66
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Smoking is a strong environmental factor leading to adverse outcomes in Crohn's disease, but a more benign course in ulcerative colitis. Several single nucleotide polymorphisms (SNPs) are associated with smoking quantity and behaviour.
To assess whether smoking-associated SNPs interact with smoking to influence the clinical course of inflammatory bowel diseases.
Genetic and prospectively obtained clinical data from 1434 Swiss inflammatory bowel disease cohort patients (821 Crohn's disease and 613 ulcerative colitis) were analysed. Six SNPs associated with smoking quantity and behaviour (rs588765, rs1051730, rs1329650, rs4105144, rs6474412 and rs3733829) were combined to form a risk score (range: 0-12) by adding the number of risk alleles. We calculated multivariate models for smoking, risk of surgery, fistula, Crohn's disease location and ulcerative colitis disease extent.
In Crohn's disease patients who smoke, the number of surgeries was associated with the genetic risk score. This translates to a predicted 3.5-fold (95% confidence interval: 2.4- to 5.7-fold, P<.0001) higher number of surgical procedures in smokers with 12 risk alleles than individuals with the lowest risk. Patients with a risk score >7 had a significantly shorter time to first intestinal surgery. The genetic risk score did not predict surgery in ulcerative colitis or occurrence of fistulae in Crohn's disease. SNP rs6265 was associated with ileal disease in Crohn's disease (P<.05) and proctitis in ulcerative colitis (P<.05).
SNPs associated with smoking quantity is associated with an increased risk for surgery in Crohn's disease patients who smoke. Our data provide an example of genetics interacting with the environment to influence the disease course of inflammatory bowel disease.
Sujets

Adult

Alleles

Cohort Studies

Colitis, Ulcerative/g...

Colitis, Ulcerative/s...

Crohn Disease/genetic...

Crohn Disease/surgery...

Female

Humans

Longitudinal Studies

Male

Middle Aged

Polymorphism, Single ...

Proctitis/epidemiolog...

Prospective Studies

Risk Factors

Smoking/adverse effec...

Smoking/epidemiology

Young Adult

PID Serval
serval:BIB_AA99F97912AB
DOI
10.1111/apt.14378
PMID
29052254
WOS
000417649400007
Permalien
https://iris.unil.ch/handle/iris/190769
Date de création
2019-01-14T15:05:20.278Z
Date de création dans IRIS
2025-05-21T01:49:45Z
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