Titre
Association of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study.
Type
article
Institution
Externe
Auteur(s)
Blum, D.
Auteure/Auteur
Cailliau, E.
Auteure/Auteur
Béhal, H.
Auteure/Auteur
Vidal, J.S.
Auteure/Auteur
Delaby, C.
Auteure/Auteur
Buée, L.
Auteure/Auteur
Allinquant, B.
Auteure/Auteur
Gabelle, A.
Auteure/Auteur
Bombois, S.
Auteure/Auteur
Lehmann, S.
Auteure/Auteur
Schraen-Maschke, S.
Auteure/Auteur
Hanon, O.
Auteure/Auteur
Contributrices/contributeurs
Hanon, O.
Blanc, F.
Boudali, Y.
Gabelle, A.
Touchon, J.
Seux, M.L.
Lenoir, H.
Bayle, C.
Bombois, S.
Delmaire, C.
Delbeuck, X.
Moulin, F.
Duron, E.
Latour, F.
Plichart, M.
Pichierri, S.
Orvoën, G.
Galbrun, E.
Castelnovo, G.
Volpe-Gillot, L.
Labourée, F.
Cassagnaud, P.
Paquet, C.
Lala, F.
Vellas, B.
Dumurgier, J.
Rigaud, A.S.
Perret-Guillaume, C.
Alonso, E.
du Boisgueheneuc, F.
Hugonot-Diener, L.
Rollin-Sillaire, A.
Martinaud, O.
Boully, C.
Spivac, Y.
Devendeville, A.
Belmin, J.
Robert, P.
Dantoine, T.
Caillard, L.
Wallon, D.
Hannequin, D.
Sastre, N.
Haffen, S.
Kearney-Schwartz, A.
Novella, J.L.
Deramecourt, V.
Chauvire, V.
Abitbol, G.
Schwald, N.
Hommet, C.
Sellal, F.
Cariot, M.A.
Abdellaoui, M.
Benisty, S.
Gherabli, S.
Anthony, P.
Bloch, F.
Charasz, N.
Chauvelier, S.
Gaubert, J.Y.
Sacco, G.
Guerin, O.
Boddaert, J.
Paccalin, M.
Mackowiak, M.A.
Rabus, M.T.
Gissot, V.
Benetos, A.
Picard, C.
Guillemaud, C.
Berrut, G.
Gervais, C.
Hugon, J.
Michel, J.M.
David, J.
Paulin, M.
Ousset, P.J.
Vandel, P.
Pariel, S.
Camus, V.
Chawakilian, A.
Kermanac'h, L.
Troussiere, A.C.
Adam, C.
Dupuy, D.
Paillaud, E.
Briault, H.
Saulnier, I.
Mondon, K.
Picat, M.A.
Laurent, M.
Godefroy, O.
Daheb, R.
Libercier, S.
Krabchi, D.
Chupin, M.
Vidal, J.
Chaussade, E.
Baret-Rose, C.
Lehmann, S.
Allinquant, B.
Schraen-Maschke, S.
Groupes de travail
BALTAZAR study group
Liens vers les personnes
ISSN
1552-5279
Statut éditorial
Publié
Date de publication
2024-10
Volume
20
Numéro
10
Première page
6948
Dernière page/numéro d’article
6959
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
We investigated the link between habitual caffeine intake with memory impairments and cerebrospinal fluid (CSF) biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients.
MCI (N = 147) and AD (N = 116) patients of the Biomarker of AmyLoid pepTide and AlZheimer's diseAse Risk (BALTAZAR) cohort reported their caffeine intake at inclusion using a dedicated survey. Associations of caffeine consumption with memory impairments and CSF biomarkers (tau, p-tau181, amyloid beta 1-42 [Aβ <sub>1-42</sub> ], Aβ <sub>1-40</sub> ) were analyzed using logistic and analysis of covariance models.
Adjusted on Apolipoprotein E (APOE ε4), age, sex, education level, and tobacco, lower caffeine consumption was associated with higher risk to be amnestic (OR: 2.49 [95% CI: 1.13 to 5.46]; p = 0.023) and lower CSF Aβ <sub>1-42</sub> (p = 0.047), Aβ <sub>1-42</sub> /Aβ <sub>1-40</sub> (p = 0.040), and Aβ <sub>1-42</sub> /p-tau181 (p = 0.020) in the whole cohort.
Data support the beneficial effect of caffeine consumption to memory impairments and CSF amyloid markers in MCI and AD patients.
We studied the impact of caffeine consumption in the BALTAZAR cohort. Low caffeine intake is associated with higher risk of being amnestic in MCI/AD patients. Caffeine intake is associated with CSF biomarkers in AD patients.
MCI (N = 147) and AD (N = 116) patients of the Biomarker of AmyLoid pepTide and AlZheimer's diseAse Risk (BALTAZAR) cohort reported their caffeine intake at inclusion using a dedicated survey. Associations of caffeine consumption with memory impairments and CSF biomarkers (tau, p-tau181, amyloid beta 1-42 [Aβ <sub>1-42</sub> ], Aβ <sub>1-40</sub> ) were analyzed using logistic and analysis of covariance models.
Adjusted on Apolipoprotein E (APOE ε4), age, sex, education level, and tobacco, lower caffeine consumption was associated with higher risk to be amnestic (OR: 2.49 [95% CI: 1.13 to 5.46]; p = 0.023) and lower CSF Aβ <sub>1-42</sub> (p = 0.047), Aβ <sub>1-42</sub> /Aβ <sub>1-40</sub> (p = 0.040), and Aβ <sub>1-42</sub> /p-tau181 (p = 0.020) in the whole cohort.
Data support the beneficial effect of caffeine consumption to memory impairments and CSF amyloid markers in MCI and AD patients.
We studied the impact of caffeine consumption in the BALTAZAR cohort. Low caffeine intake is associated with higher risk of being amnestic in MCI/AD patients. Caffeine intake is associated with CSF biomarkers in AD patients.
PID Serval
serval:BIB_FBA183497F6C
PMID
Open Access
Oui
Date de création
2025-03-05T09:10:48.495Z
Date de création dans IRIS
2025-05-21T07:22:29Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
ALZ-20-6948.pdf
Version du manuscrit
preprint
Licence
https://creativecommons.org/licenses/by/4.0
Taille
314.76 KB
Format
Adobe PDF
PID Serval
serval:BIB_FBA183497F6C.P001
Somme de contrôle
(MD5):43d89ca89a98094c06fd2010db22aaad