Titre
Psychiatric comorbidity and additional abuse of drugs in maintenance treatment with l- and d,l-methadone.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Wedekind, D.
Auteure/Auteur
Jacobs, S.
Auteure/Auteur
Karg, I.
Auteure/Auteur
Luedecke, C.
Auteure/Auteur
Schneider, U.
Auteure/Auteur
Cimander, K.
Auteure/Auteur
Baumann, P.
Auteure/Auteur
Ruether, E.
Auteure/Auteur
Poser, W.
Auteure/Auteur
Havemann-Reinecke, U.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1814-1412[electronic], 1562-2975[linking]
Statut éditorial
Publié
Date de publication
2008
Volume
9
Première page
1
Dernière page/numéro d’article
10
Peer-reviewed
Oui
Langue
anglais
Résumé
Sixty d,l- or l-methadone treated patients in maintenance therapy were interviewed for additional drug abuse and psychiatric comorbidity; 51.7% of the entire population had a comorbid Axis-I disorder, with a higher prevalence in females (P=0.05). Comorbid patients tended to have higher abuse of benzodiazepines, alcohol, cannabis, and cocaine, but not of heroin. They had received a significantly lower d,l- (P<0.05) and l-methadone dose than non-comorbid subjects. The duration of maintenance treatment showed an inverse relationship to frequency of additional heroin intake (P<0.01). Patients with additional heroin intake over the past 30 days had been treated with a significantly lower l-methadone dosage (P<0.05) than patients without. Axis-I comorbidity appears to be decreased when relatively higher dosages of d,l- (and l-methadone) are administered; comorbid individuals, however, were on significantly lower dosages. Finally, l-, but not d,l-methadone seems to be more effective in reducing additional heroin abuse.
PID Serval
serval:BIB_14D1FF1E78F1
PMID
Date de création
2008-10-21T13:07:02.915Z
Date de création dans IRIS
2025-05-20T20:05:46Z