Titre
Control of immune cell function by the unfolded protein response.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Di Conza, G.
Auteure/Auteur
Ho, P.C.
Auteure/Auteur
Cubillos-Ruiz, J.R.
Auteure/Auteur
Huang, S.C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1474-1741
Statut éditorial
Publié
Date de publication
2023-09
Volume
23
Numéro
9
Première page
546
Dernière page/numéro d’article
562
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
Initiating and maintaining optimal immune responses requires high levels of protein synthesis, folding, modification and trafficking in leukocytes, which are processes orchestrated by the endoplasmic reticulum. Importantly, diverse extracellular and intracellular conditions can compromise the protein-handling capacity of this organelle, inducing a state of 'endoplasmic reticulum stress' that activates the unfolded protein response (UPR). Emerging evidence shows that physiological or pathological activation of the UPR can have effects on immune cell survival, metabolism, function and fate. In this Review, we discuss the canonical role of the adaptive UPR in immune cells and how dysregulation of this pathway in leukocytes contributes to diverse pathologies such as cancer, autoimmunity and metabolic disorders. Furthermore, we provide an overview as to how pharmacological approaches that modulate the UPR could be harnessed to control or activate immune cell function in disease.
PID Serval
serval:BIB_84EB04B67D6F
PMID
Date de création
2023-03-03T13:21:29.166Z
Date de création dans IRIS
2025-05-21T03:45:31Z