Titre

Strong impact of smoking on multimorbidity and cardiovascular risk among human immunodeficiency virus-infected individuals in comparison with the general population.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Hasse, B.
Auteure/Auteur
Tarr, P.E.
Auteure/Auteur
Marques-Vidal, P.
Auteure/Auteur
Waeber, G.
Auteure/Auteur
Preisig, M.
Auteure/Auteur
Mooser, V.
Auteure/Auteur
Valeri, F.
Auteure/Auteur
Djalali, S.
Auteure/Auteur
Andri, R.
Auteure/Auteur
Bernasconi, E.
Auteure/Auteur
Calmy, A.
Auteure/Auteur
Cavassini, M.
Auteure/Auteur
Vernazza, P.
Auteure/Auteur
Battegay, M.
Auteure/Auteur
Weber, R.
Auteure/Auteur
Senn, O.
Auteure/Auteur
Vollenweider, P.
Auteure/Auteur
Ledergerber, B.
Auteure/Auteur
FIRE,
Auteure/Auteur
Contributrices/contributeurs
Aubert, V.
Barth, J.
Battegay, M.
Bernasconi, E.
Böni, J.
Bucher, H.C.
Burton-Jeangros, C.
Calmy, A.
Egger, M.
Elzi, L.
Fehr, J.
Fellay, J.
Furrer, H.
Fux, C.A.
Gorgievski, M.
Günthard, H.
Haerry, D.
Hasse, B.
Hirsch, H.H.
Hösli, I.
Kahlert, C.
Kaiser, L.
Keiser, O.
Klimkait, T.
Kouyos, R.
Kovari, H.
Ledergerber, B.
Martinetti, G.
Martinez de Tejada, B.
Metzner, K.
Müller, N.
Nadal, D.
Pantaleo, G.
Rauch, A.
Regenass, S.
Rickenbach, M.
Rudin, C.
Schöni-Affolter, F.
Schmid, P.
Schultze, D.
Schüpbach, J.
Speck, R.
Staehelin, C.
Tarr, P.
Telenti, A.
Trkola, A.
Vernazza, P.
Weber, R.
Yerly, S.
Aubert, V.
Barth, J.
Battegay, M.
Bernasconi, E.
Böni, J.
Bucher, H.C.
Burton-Jeangros, C.
Calmy, A.
Egger, M.
Elzi, L.
Fehr, J.
Fellay, J.
Furrer, H.
Fux, C.A.
Gorgievski, M.
Günthard, H.
Haerry, D.
Hasse, B.
Hirsch, H.H.
Hösli, I.
Kahlert, C.
Kaiser, L.
Keiser, O.
Klimkait, T.
Kouyos, R.
Kovari, H.
Ledergerber, B.
Martinetti, G.
Martinez de Tejada, B.
Metzner, K.
Müller, N.
Nadal, D.
Pantaleo, G.
Rauch, A.
Regenass, S.
Rickenbach, M.
Rudin, C.
Schöni-Affolter, F.
Schmid, P.
Schultze, D.
Schüpbach, J.
Speck, R.
Staehelin, C.
Tarr, P.
Telenti, A.
Trkola, A.
Vernazza, P.
Weber, R.
Yerly, S.
Jean-Michel, A.
Murielle, B.
Jean Michel, G.
Christoph, H.
Thomas, L.
Pedro, M.V.
Vincent, M.
Fred, P.
Martin, P.
Peter, V.
Roland, V.K.
Aidacic, V.
Gerard, W.
Jürg, B.
Markus, B.
Heinz, B.
Martin, B.
Hans-Ulrich, B.
Ivo, B.
Reto, C.
Isabelle, C.
Corinne, C.
Sima, D.
Peter, D.
Simone, E.
Andrea, F.
Markus, F.
Claudius, F.
Jakob, F.
Ali, G.M.
Matthias, G.
Denis, H.
Marcel, H.
Walter, H.
Simon, H.
Felix, H.
Paul, H.
Eva, K.
Vladimir, K.
Daniel, K.
Stephan, K.
Beat, K.
Benedict, K.
Heidi, K.
Vesna, L.
Giovanni, L.
Werner, L.H.
Phillippe, L.
Severin, L.
Christoph, M.
Jürgen, M.
Damian, M.
Werner, M.
Titus, M.
Valentina, N.
Jakob, R.
Thomas, R.
Hana, S.
Frank, S.
Georg, S.
Oliver, S.
Pietro, S.
Jacques, S.
Alfred, S.
Alois, S.
Claudia, S.
Othmar, S.
Phuoc, T.T.
Marco, V.
Alessandro, V.
René, V.A.
Hans, W.
Fritz, W.
Johanna, W.S.
Joseph, W.
Marco, Z.
Groupes de travail
CoLaus Cohort
Liens vers les personnes
Liens vers les unités
ISSN
2328-8957
Statut éditorial
Publié
Date de publication
2015
Volume
2
Numéro
3
Première page
ofv108
Peer-reviewed
Oui
Langue
anglais
Notes
Publication Status: epublish
Résumé
Background.  Although acquired immune deficiency syndrome-associated morbidity has diminished due to excellent viral control, multimorbidity may be increasing among human immunodeficiency virus (HIV)-infected persons compared with the general population. Methods.  We assessed the prevalence of comorbidities and multimorbidity in participants of the Swiss HIV Cohort Study (SHCS) compared with the population-based CoLaus study and the primary care-based FIRE (Family Medicine ICPC-Research using Electronic Medical Records) records. The incidence of the respective endpoints were assessed among SHCS and CoLaus participants. Poisson regression models were adjusted for age, sex, body mass index, and smoking. Results.  Overall, 74 291 participants contributed data to prevalence analyses (3230 HIV-infected; 71 061 controls). In CoLaus, FIRE, and SHCS, multimorbidity was present among 26%, 13%, and 27% of participants. Compared with nonsmoking individuals from CoLaus, the incidence of cardiovascular disease was elevated among smoking individuals but independent of HIV status (HIV-negative smoking: incidence rate ratio [IRR] = 1.7, 95% confidence interval [CI] = 1.2-2.5; HIV-positive smoking: IRR = 1.7, 95% CI = 1.1-2.6; HIV-positive nonsmoking: IRR = 0.79, 95% CI = 0.44-1.4). Compared with nonsmoking HIV-negative persons, multivariable Poisson regression identified associations of HIV infection with hypertension (nonsmoking: IRR = 1.9, 95% CI = 1.5-2.4; smoking: IRR = 2.0, 95% CI = 1.6-2.4), kidney (nonsmoking: IRR = 2.7, 95% CI = 1.9-3.8; smoking: IRR = 2.6, 95% CI = 1.9-3.6), and liver disease (nonsmoking: IRR = 1.8, 95% CI = 1.4-2.4; smoking: IRR = 1.7, 95% CI = 1.4-2.2). No evidence was found for an association of HIV-infection or smoking with diabetes mellitus. Conclusions.  Multimorbidity is more prevalent and incident in HIV-positive compared with HIV-negative individuals. Smoking, but not HIV status, has a strong impact on cardiovascular risk and multimorbidity.
PID Serval
serval:BIB_BB00A4302053
DOI
PMID
Permalien
Open Access
Oui
Date de création
2015-09-11T07:58:36.910Z
Date de création dans IRIS
2025-05-20T23:15:30Z
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ofv108.pdf

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published

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255.71 KB

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Adobe PDF

PID Serval

serval:BIB_BB00A4302053.P001

URN

urn:nbn:ch:serval-BIB_BB00A43020531

Somme de contrôle

(MD5):6ce4d7034a517d193c63a5e458ad2dec