Titre
Healthy Organs Uptake on Baseline <sup>18</sup>F-FDG PET/CT as an Alternative to Total Metabolic Tumor Volume to Predict Event-Free Survival in Classical Hodgkin's Lymphoma.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Morland, D.
Auteure/Auteur
Triumbari, EKA
Auteure/Auteur
Maiolo, E.
Auteure/Auteur
Cuccaro, A.
Auteure/Auteur
Treglia, G.
Auteure/Auteur
Hohaus, S.
Auteure/Auteur
Annunziata, S.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2296-858X
Statut éditorial
Publié
Date de publication
2022
Volume
9
Première page
913866
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Healthy organs uptake, including cerebellar and liver SUVs have been reported to be inversely correlated to total metabolic tumor volume (TMTV), a controversial predictor of event-free survival (EFS) in classical Hodgkin's Lymphoma (cHL). The objective of this study was to estimate TMTV by using healthy organs SUV measurements and assess the performance of this new index (UF, Uptake Formula) to predict EFS in cHL.
Patients with cHL were retrospectively included. SUV values and TMTV derived from baseline <sup>18</sup> F-FDG PET/CT were harmonized using ComBat algorithm across PET/CT systems. UF was estimated using ANOVA analysis. Optimal thresholds of TMTV and UF were calculated and tested using Cox models.
163 patients were included. Optimal UF model of TMTV included age, lymphoma maximum SUVmax, hepatic SUVmean and cerebellar SUVmax (R <sup>2</sup> 14.0% - p < 0.001). UF > 236.8 was a significant predictor of EFS (HR: 2.458 [1.201-5.030], p = 0.01) and was not significantly different from TMTV > 271.0 (HR: 2.761 [1.183-5.140], p = 0.001). UF > 236.8 remained significant in a bivariate model including IPS score (p = 0.02) and determined two populations with different EFS (63.7 vs. 84.9%, p = 0.01).
The Uptake Formula, a new index including healthy organ SUV values, shows similar performance to TMTV in predicting EFS in Hodgkin's Lymphoma. Validation cohorts will be needed to confirm this new prognostic parameter.
Patients with cHL were retrospectively included. SUV values and TMTV derived from baseline <sup>18</sup> F-FDG PET/CT were harmonized using ComBat algorithm across PET/CT systems. UF was estimated using ANOVA analysis. Optimal thresholds of TMTV and UF were calculated and tested using Cox models.
163 patients were included. Optimal UF model of TMTV included age, lymphoma maximum SUVmax, hepatic SUVmean and cerebellar SUVmax (R <sup>2</sup> 14.0% - p < 0.001). UF > 236.8 was a significant predictor of EFS (HR: 2.458 [1.201-5.030], p = 0.01) and was not significantly different from TMTV > 271.0 (HR: 2.761 [1.183-5.140], p = 0.001). UF > 236.8 remained significant in a bivariate model including IPS score (p = 0.02) and determined two populations with different EFS (63.7 vs. 84.9%, p = 0.01).
The Uptake Formula, a new index including healthy organ SUV values, shows similar performance to TMTV in predicting EFS in Hodgkin's Lymphoma. Validation cohorts will be needed to confirm this new prognostic parameter.
PID Serval
serval:BIB_8E77EFFEE942
PMID
Open Access
Oui
Date de création
2022-07-18T08:28:48.610Z
Date de création dans IRIS
2025-05-21T01:42:16Z
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Nom
35814740_BIB_8E77EFFEE942.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
675.52 KB
Format
Adobe PDF
PID Serval
serval:BIB_8E77EFFEE942.P001
URN
urn:nbn:ch:serval-BIB_8E77EFFEE9420
Somme de contrôle
(MD5):47fac5209afb08813c03a006bc919261