Titre
Brain-Periphery Interactions in Huntington's Disease: Mediators and Lifestyle Interventions.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Burtscher, J.
Auteure/Auteur
Strasser, B.
Auteure/Auteur
Pepe, G.
Auteure/Auteur
Burtscher, M.
Auteure/Auteur
Kopp, M.
Auteure/Auteur
Di Pardo, A.
Auteure/Auteur
Maglione, V.
Auteure/Auteur
Khamoui, A.V.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1422-0067
Statut éditorial
Publié
Date de publication
2024-04-25
Volume
25
Numéro
9
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
Prominent pathological features of Huntington's disease (HD) are aggregations of mutated Huntingtin protein (mHtt) in the brain and neurodegeneration, which causes characteristic motor (such as chorea and dystonia) and non-motor symptoms. However, the numerous systemic and peripheral deficits in HD have gained increasing attention recently, since those factors likely modulate disease progression, including brain pathology. While whole-body metabolic abnormalities and organ-specific pathologies in HD have been relatively well described, the potential mediators of compromised inter-organ communication in HD have been insufficiently characterized. Therefore, we applied an exploratory literature search to identify such mediators. Unsurprisingly, dysregulation of inflammatory factors, circulating mHtt, and many other messenger molecules (hormones, lipids, RNAs) were found that suggest impaired inter-organ communication, including of the gut-brain and muscle-brain axis. Based on these findings, we aimed to assess the risks and potentials of lifestyle interventions that are thought to improve communication across these axes: dietary strategies and exercise. We conclude that appropriate lifestyle interventions have great potential to reduce symptoms and potentially modify disease progression (possibly via improving inter-organ signaling) in HD. However, impaired systemic metabolism and peripheral symptoms warrant particular care in the design of dietary and exercise programs for people with HD.
PID Serval
serval:BIB_735ED8063CC7
PMID
Open Access
Oui
Date de création
2024-05-16T12:58:12.396Z
Date de création dans IRIS
2025-05-20T22:26:56Z
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Nom
38731912_BIB_735ED8063CC7.pdf
Version du manuscrit
preprint
Licence
https://creativecommons.org/licenses/by/4.0
Taille
1.51 MB
Format
Adobe PDF
PID Serval
serval:BIB_735ED8063CC7.P001
URN
urn:nbn:ch:serval-BIB_735ED8063CC77
Somme de contrôle
(MD5):0ac55f9913e803df6e748a06300a0b42