Titre
Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Karam, O.
Auteure/Auteur
Demaret, P.
Auteure/Auteur
Duhamel, A.
Auteure/Auteur
Shefler, A.
Auteure/Auteur
Spinella, P.C.
Auteure/Auteur
Stanworth, S.J.
Auteure/Auteur
Tucci, M.
Auteure/Auteur
Leteurtre, S.
Auteure/Auteur
Contributrices/contributeurs
Butt, W.
Delzoppo, C.
Bain, K.
Erickson, S.
Smalley, N.
Dorofaeff, T.
Long, D.
Wiseman, G.
Clénent de Cléty, S.
Berghe, C.
de Jaeger, A.
Demaret, P.
Trippaerts, M.
Willems, A.
Rooze, S.
De Dooy, J.
Gilfoyle, E.
Wohlgemuth, L.
Tucci, M.
Dumitrascu, M.
Withington, D.
Hickey, J.
Choong, K.
Sanders, L.
Morrison, G.
Tijssen, J.
Wensley, D.
Krahn, G.
Dugas, M.A.
Gosselin, L.
Santschi, M.
Von Dessauer, B.
Ordenes, N.
Afshari, A.
Andersen, L.H.
Nilsson, J.C.
Johansen, M.
Baek Jensen, A.M.
Campos Mino, S.
Grunauer, M.
Joram, N.
Roullet-Renoleau, N.
Javouhey, E.
Cour-Andlauer, F.
Portefaix, A.
Brissaud, O.
Guichoux, J.
Payen, V.
Léger, P.L.
Afanetti, M.
Mortamet, G.
Maria, M.
Breining, A.
Tissieres, P.
Dorkenoo, A.
Deho, A.
Steinherr, H.
Nikolaou, F.
Camporesi, A.
Mario, F.
Kawasaki, T.
Miura, S.
Beca, J.
Rea, M.
Sherring, C.
Bushell, T.
Bentsen, G.
Dinis, A.
Pereira, G.
Vieira, M.
Moniz, M.
Alshehri, S.
Alasnag, M.
Pisarcikova, M.
Jordan, I.
Balcells, J.
Perez-Ferrer, A.
de Vicente Sánchez, J.
Vazquez Moyano, M.
Morales Martinez, A.
Lopez-Herce, J.
Solana, M.J.
Flores González, J.C.
Alonso, M.T.
Nieto Faza, M.
Perez, M.H.
Amiet, V.
Doell, C.
Bordessoule, A.
Cochius-den Otter, S.
Kapitein, B.
Kneyber, M.
Brierley, J.
Rea, V.
McKeever, S.
Kelleher, A.
Scholefield, B.
Top, A.
Kelly, N.
Virdee, S.
Davis, P.
George, S.
Hawkins, K.C.
McCall, K.
Brown, V.
Sykes, K.
Levin, R.
MacLeod, I.
Horan, M.
Jirasek, P.
Inwald, D.
Abdulla, A.
Raghunanan, S.
Taylor, B.
Shefler, A.
Sparkes, H.
Hanson, S.
Woods, K.
Triscari, D.
Murkowski, K.
Ozment, C.
Steiner, M.
Nerheim, D.
Galster, A.
Higgerson, R.
Christie, L.
Spinella, P.C.
Martin, D.
Rourke, L.
Muszynski, J.
Steele, L.
Ajizian, S.
McCrory, M.C.
O'Brien, K.
Babbitt, C.
Felkel, E.
Levine, G.
Truemper, E.J.
Zink, M.
Nellis, M.
Thomas, N.J.
Spear, D.
Markovitz, B.
Terry, J.
Morzov, R.
Montgomery, V.
Michael, A.
Thomas, M.
Singleton, M.
Jarvis, D.
Nett, S.
Willson, D.
Hoot, M.
Bembea, M.
Yiu, A.
McKinley, D.
Scarlett, E.
Sankey, J.
Parikh, M.
Faustino, EVS
Michelson, K.
Rilinger, J.
Campbell, L.
Gertz, S.
Cholette, J.M.
Jeyapalan, A.
Parker, M.
Bateman, S.
Johnson, A.
Groupes de travail
PlasmaTV investigators
Liens vers les personnes
Liens vers les unités
ISSN
2110-5820
Statut éditorial
Publié
Date de publication
2016-12
Volume
6
Numéro
1
Première page
98
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions.
This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer-Lemeshow test).
Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71-0.81) and the Hosmer-Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1.
In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.
This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer-Lemeshow test).
Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71-0.81) and the Hosmer-Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1.
In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.
PID Serval
serval:BIB_E611B0AC7C4C
PMID
Open Access
Oui
Date de création
2018-05-01T07:22:29.855Z
Date de création dans IRIS
2025-05-21T05:35:39Z
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Nom
27714707_BIB_E611B0AC7C4C.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
870.42 KB
Format
Adobe PDF
PID Serval
serval:BIB_E611B0AC7C4C.P001
URN
urn:nbn:ch:serval-BIB_E611B0AC7C4C3
Somme de contrôle
(MD5):45766e3a97ee9ac781ac396bf4f7ac48